FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038287336> ?p ?o ?g. }

• W2038287336 endingPage "7881" @default.
• W2038287336 startingPage "7874" @default.
• W2038287336 abstract "Abstract Neuroblastoma is an often fatal pediatric cancer arising from precursor cells of the sympathetic nervous system. 13-Cis retinoic acid is included in the treatment regimen for patients with high-risk disease, and a similar derivative, all-trans-retinoic acid (ATRA), causes neuroblastoma cell lines to undergo differentiation. The molecular signaling pathways involved with ATRA-induced differentiation are complex, and the role that DNA methylation changes might play are unknown. The purpose of this study was to evaluate the genome-wide effects of ATRA on DNA methylation using methylated DNA immunoprecipitation applied to microarrays representing all known promoter and CpG islands. Four hundred and two gene promoters became demethylated, whereas 88 were hypermethylated post-ATRA. mRNA expression microarrays revealed that 82 of the demethylated genes were overexpressed by &gt;2-fold, whereas 13 of the hypermethylated genes were underexpressed. Gene ontology analysis indicated that demethylated and re-expressed genes were enriched for signal transduction pathways, including NOS1, which is required for neural cell differentiation. As a potential mechanism for the DNA methylation changes, we show the downregulation of methyltransferases, DNMT1 and DNMT3B, along with the upregulation of endogenous microRNAs targeting them. Ectopic overexpression of miR-152, targeting DNMT1, also negatively affected cell invasiveness and anchorage-independent growth, contributing in part to the differentiated phenotype. We conclude that functionally important, miRNA-mediated DNA demethylation changes contribute to the process of ATRA-induced differentiation resulting in the activation of NOS1, a critical determinant of neural cell differentiation. Our findings illustrate the plasticity and dynamic nature of the epigenome during cancer cell differentiation. Cancer Res; 70(20); 7874–81. ©2010 AACR." @default.
• W2038287336 created "2016-06-24" @default.
• W2038287336 creator A5002015541 @default.
• W2038287336 creator A5013175327 @default.
• W2038287336 creator A5018614325 @default.
• W2038287336 creator A5024265298 @default.
• W2038287336 creator A5044144357 @default.
• W2038287336 creator A5052099004 @default.
• W2038287336 creator A5070841986 @default.
• W2038287336 creator A5085797243 @default.
• W2038287336 date "2010-10-13" @default.
• W2038287336 modified "2023-10-16" @default.
• W2038287336 title "MicroRNA Mediates DNA Demethylation Events Triggered by Retinoic Acid during Neuroblastoma Cell Differentiation" @default.
• W2038287336 cites W169581500 @default.
• W2038287336 cites W1969951398 @default.
• W2038287336 cites W1988993069 @default.
• W2038287336 cites W1989421786 @default.
• W2038287336 cites W2001117361 @default.
• W2038287336 cites W2007179439 @default.
• W2038287336 cites W2024280594 @default.
• W2038287336 cites W2050249744 @default.
• W2038287336 cites W2064428081 @default.
• W2038287336 cites W2067606868 @default.
• W2038287336 cites W2089122694 @default.
• W2038287336 cites W2104784323 @default.
• W2038287336 cites W2114296097 @default.
• W2038287336 cites W2120865735 @default.
• W2038287336 cites W2129646934 @default.
• W2038287336 cites W2132798049 @default.
• W2038287336 cites W2138809862 @default.
• W2038287336 cites W2145909370 @default.
• W2038287336 cites W2152122421 @default.
• W2038287336 cites W2161584400 @default.
• W2038287336 cites W2170989872 @default.
• W2038287336 cites W2330923897 @default.
• W2038287336 cites W2142808522 @default.
• W2038287336 doi "https://doi.org/10.1158/0008-5472.can-10-1534" @default.
• W2038287336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2955783" @default.
• W2038287336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20841484" @default.
• W2038287336 hasPublicationYear "2010" @default.
• W2038287336 type Work @default.
• W2038287336 sameAs 2038287336 @default.
• W2038287336 citedByCount "102" @default.
• W2038287336 countsByYear W20382873362012 @default.
• W2038287336 countsByYear W20382873362013 @default.
• W2038287336 countsByYear W20382873362014 @default.
• W2038287336 countsByYear W20382873362015 @default.
• W2038287336 countsByYear W20382873362016 @default.
• W2038287336 countsByYear W20382873362017 @default.
• W2038287336 countsByYear W20382873362018 @default.
• W2038287336 countsByYear W20382873362019 @default.
• W2038287336 countsByYear W20382873362020 @default.
• W2038287336 countsByYear W20382873362021 @default.
• W2038287336 countsByYear W20382873362022 @default.
• W2038287336 countsByYear W20382873362023 @default.
• W2038287336 crossrefType "journal-article" @default.
• W2038287336 hasAuthorship W2038287336A5002015541 @default.
• W2038287336 hasAuthorship W2038287336A5013175327 @default.
• W2038287336 hasAuthorship W2038287336A5018614325 @default.
• W2038287336 hasAuthorship W2038287336A5024265298 @default.
• W2038287336 hasAuthorship W2038287336A5044144357 @default.
• W2038287336 hasAuthorship W2038287336A5052099004 @default.
• W2038287336 hasAuthorship W2038287336A5070841986 @default.
• W2038287336 hasAuthorship W2038287336A5085797243 @default.
• W2038287336 hasBestOaLocation W20382873361 @default.
• W2038287336 hasConcept C104317684 @default.
• W2038287336 hasConcept C148738053 @default.
• W2038287336 hasConcept C150194340 @default.
• W2038287336 hasConcept C153911025 @default.
• W2038287336 hasConcept C16824249 @default.
• W2038287336 hasConcept C190727270 @default.
• W2038287336 hasConcept C2779963572 @default.
• W2038287336 hasConcept C2781121885 @default.
• W2038287336 hasConcept C502942594 @default.
• W2038287336 hasConcept C54355233 @default.
• W2038287336 hasConcept C86803240 @default.
• W2038287336 hasConceptScore W2038287336C104317684 @default.
• W2038287336 hasConceptScore W2038287336C148738053 @default.
• W2038287336 hasConceptScore W2038287336C150194340 @default.
• W2038287336 hasConceptScore W2038287336C153911025 @default.
• W2038287336 hasConceptScore W2038287336C16824249 @default.
• W2038287336 hasConceptScore W2038287336C190727270 @default.
• W2038287336 hasConceptScore W2038287336C2779963572 @default.
• W2038287336 hasConceptScore W2038287336C2781121885 @default.
• W2038287336 hasConceptScore W2038287336C502942594 @default.
• W2038287336 hasConceptScore W2038287336C54355233 @default.
• W2038287336 hasConceptScore W2038287336C86803240 @default.
• W2038287336 hasIssue "20" @default.
• W2038287336 hasLocation W20382873361 @default.
• W2038287336 hasLocation W20382873362 @default.
• W2038287336 hasLocation W20382873363 @default.
• W2038287336 hasLocation W20382873364 @default.
• W2038287336 hasOpenAccess W2038287336 @default.
• W2038287336 hasPrimaryLocation W20382873361 @default.
• W2038287336 hasRelatedWork W1948342112 @default.
• W2038287336 hasRelatedWork W1974006411 @default.
• W2038287336 hasRelatedWork W2038287336 @default.
• W2038287336 hasRelatedWork W2077157877 @default.

• next