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• W2038290292 abstract "Zebrafish are an excellent model for Duchenne muscular dystrophy. In particular, zebrafish provide a system for rapid, easy, and low-cost screening of small molecules that can ameliorate muscle damage in dystrophic larvae. Here we identify an optimal anti-sense morpholino cocktail that robustly knocks down zebrafish Dystrophin (dmd-MO). We use two approaches, muscle birefringence and muscle actin expression, to quantify muscle damage and show that the dmd-MO dystrophic phenotype closely resembles the zebrafish dmd mutant phenotype. We then show that the histone deacetylase (HDAC) inhibitor TSA, which has been shown to ameliorate the mdx mouse Duchenne model, can rescue muscle fiber damage in both dmd-MO and dmd mutant larvae. Our study identifies optimal morpholino and phenotypic scoring approaches for dystrophic zebrafish, further enhancing the zebrafish dmd model for rapid and cost-effective small molecule screening." @default.
• W2038290292 created "2016-06-24" @default.
• W2038290292 creator A5030788378 @default.
• W2038290292 creator A5053082993 @default.
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• W2038290292 date "2013-01-01" @default.
• W2038290292 modified "2023-09-27" @default.
• W2038290292 title "The HDAC Inhibitor TSA Ameliorates a Zebrafish Model of Duchenne Muscular Dystrophy" @default.
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• W2038290292 doi "https://doi.org/10.1371/currents.md.8273cf41db10e2d15dd3ab827cb4b027" @default.
• W2038290292 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3870918" @default.
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