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- W2038309936 abstract "MHC class-1-specific inhibitory receptors were originally described in NK cells, in which they represent an important fail-safe mechanism that induces NK cell tolerance to normal self cells. These inhibitory NK receptors (iNKRs) were subsequently found expressed on different T cell subsets, primarily CD8+ cytolytic T lymphocytes (CTLs), in which they can inhibit T cell receptor mediated functions. Some iNKR+ CTLs are HLA-E-restricted, represent oligo- or monoclonal expansions, and can play a defensive role in viral infections. Although T cell activation, in the presence of certain cytokines, can induce the expression of the CD94–NKG2A heterodimeric receptor, the mechanism leading to the expression of killer immunoglobulin-like receptors (KIRs) is still unknown. The expression of iNKRs in T cells might contribute to the prevention of apoptotic cell death, thus allowing their survival and clonal expansion in vivo. In addition, iNKR+ T cells might contribute to peripheral self-tolerance." @default.
- W2038309936 created "2016-06-24" @default.
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- W2038309936 date "2005-06-01" @default.
- W2038309936 modified "2023-10-11" @default.
- W2038309936 title "Human cytolytic T lymphocytes expressing HLA class-I-specific inhibitory receptors" @default.
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- W2038309936 doi "https://doi.org/10.1016/j.coi.2005.03.006" @default.
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