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- W2038315042 abstract "The effects of chloride channel blockers upon intracellular pH (pHi) were examined in renal epithelial monolayers of LLC-PK1 cells. A significant intracellular acidification was found with addition of 100 microM 5-nitro-2-(3-phenylpropylamino)-benzoate (NPPB), niflumic acid, flufenamate and diphenylamine-2-carboxylate (DPC) but not with 4,4'-diisothiocyanatostilbene-2-2'disulphonic acid (DIDS). The effects of these agents upon pHi was dose-dependent with apparent K0.5 values of: 16.7 +/- 0.3 microM, 34.2 +/- 0.9 microM and 740 +/- 13 microM for niflumic acid, flufenamate and DPC respectively. The results indicate that at concentrations commonly used to block channel activity these chloride channel blockers have profound effects upon pHi." @default.
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- W2038315042 date "1996-06-01" @default.
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- W2038315042 title "Chloride channel blockers decrease intracellular pH in cultured renal epithelial LLC-PK1 cells" @default.
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- W2038315042 doi "https://doi.org/10.1111/j.1476-5381.1996.tb15422.x" @default.
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