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- W2038317444 abstract "✓ A microtiter assay was used to study the sensitivity of 24 cultured human astrocytomas to the chemotherapeutic agent 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU). The tumor cell lines tested originated from patients who were being treated with postoperative chemotherapy within the past 24 months. At a dose level comparable to the maximum in vivo therapeutic dose level, 18 of the 24 cell lines tested showed a significant response to the drug. If in vitro response can eventually be correlated with clinical response, this microtiter assay could help to form a basis for planning more specific chemotherapeutic treatment." @default.
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- W2038317444 date "1978-04-01" @default.
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- W2038317444 title "Variations in response of human brain tumors to BCNU in vitro" @default.
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- W2038317444 doi "https://doi.org/10.3171/jns.1978.48.4.0580" @default.
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