Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038322010> ?p ?o ?g. }
- W2038322010 abstract "Human T-cell leukemia virus type 1 (HTLV-1) causes adult T-cell leukemia (ATL). The minus strand of HTLV-1 provirus encodes a bZIP protein donated as HTLV-1 bZIP factor (HBZ). Among the HTLV-1 regulatory and accessory genes, the tax and HBZ genes were thought to play critical roles in oncogenesis. However, HBZ is the only gene that remains intact and is consistently expressed in all ATL cases, while the tax gene is frequently inactivated by epigenetic modifications or deletion of the 5'LTR. HBZ gene promotes the proliferation of ATL cells through its mRNA form. Moreover, HBZ induces T-cell lymphoma and systemic inflammation in vivo. HBZ fulfills its functions mainly through regulating HTLV-1 5'LTR transcription and modulating a variety of cellular signaling pathways which are related with cell growth, immune response, and T-cell differentiation. Taken together, the multiple functions of HBZ render its predominant function in leukemogenesis of ATL." @default.
- W2038322010 created "2016-06-24" @default.
- W2038322010 creator A5019527890 @default.
- W2038322010 creator A5088030604 @default.
- W2038322010 date "2012-01-01" @default.
- W2038322010 modified "2023-09-29" @default.
- W2038322010 title "HBZ and its roles in HTLV-1 oncogenesis" @default.
- W2038322010 cites W1609984326 @default.
- W2038322010 cites W1964327536 @default.
- W2038322010 cites W1966278500 @default.
- W2038322010 cites W1970488098 @default.
- W2038322010 cites W1995495460 @default.
- W2038322010 cites W1999585673 @default.
- W2038322010 cites W2007022304 @default.
- W2038322010 cites W2008724419 @default.
- W2038322010 cites W2012301191 @default.
- W2038322010 cites W2016347386 @default.
- W2038322010 cites W2027392116 @default.
- W2038322010 cites W2036818178 @default.
- W2038322010 cites W2044243805 @default.
- W2038322010 cites W2048099266 @default.
- W2038322010 cites W2060063757 @default.
- W2038322010 cites W2060146090 @default.
- W2038322010 cites W2062120516 @default.
- W2038322010 cites W2068100440 @default.
- W2038322010 cites W2071794490 @default.
- W2038322010 cites W2075715912 @default.
- W2038322010 cites W2086143621 @default.
- W2038322010 cites W2092834432 @default.
- W2038322010 cites W2094098394 @default.
- W2038322010 cites W2094236991 @default.
- W2038322010 cites W2094831592 @default.
- W2038322010 cites W2101820575 @default.
- W2038322010 cites W2104358213 @default.
- W2038322010 cites W2106198927 @default.
- W2038322010 cites W2115683804 @default.
- W2038322010 cites W2121464818 @default.
- W2038322010 cites W2149377687 @default.
- W2038322010 cites W2151482423 @default.
- W2038322010 cites W2153196983 @default.
- W2038322010 cites W2153626652 @default.
- W2038322010 cites W2158178382 @default.
- W2038322010 cites W2169995647 @default.
- W2038322010 cites W2171479458 @default.
- W2038322010 cites W2336865896 @default.
- W2038322010 doi "https://doi.org/10.3389/fmicb.2012.00247" @default.
- W2038322010 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3391691" @default.
- W2038322010 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22787458" @default.
- W2038322010 hasPublicationYear "2012" @default.
- W2038322010 type Work @default.
- W2038322010 sameAs 2038322010 @default.
- W2038322010 citedByCount "69" @default.
- W2038322010 countsByYear W20383220102012 @default.
- W2038322010 countsByYear W20383220102013 @default.
- W2038322010 countsByYear W20383220102014 @default.
- W2038322010 countsByYear W20383220102015 @default.
- W2038322010 countsByYear W20383220102016 @default.
- W2038322010 countsByYear W20383220102017 @default.
- W2038322010 countsByYear W20383220102018 @default.
- W2038322010 countsByYear W20383220102019 @default.
- W2038322010 countsByYear W20383220102020 @default.
- W2038322010 countsByYear W20383220102021 @default.
- W2038322010 countsByYear W20383220102022 @default.
- W2038322010 countsByYear W20383220102023 @default.
- W2038322010 crossrefType "journal-article" @default.
- W2038322010 hasAuthorship W2038322010A5019527890 @default.
- W2038322010 hasAuthorship W2038322010A5088030604 @default.
- W2038322010 hasBestOaLocation W20383220101 @default.
- W2038322010 hasConcept C102906071 @default.
- W2038322010 hasConcept C104317684 @default.
- W2038322010 hasConcept C141231307 @default.
- W2038322010 hasConcept C159047783 @default.
- W2038322010 hasConcept C19408993 @default.
- W2038322010 hasConcept C2778461978 @default.
- W2038322010 hasConcept C41091548 @default.
- W2038322010 hasConcept C502942594 @default.
- W2038322010 hasConcept C54355233 @default.
- W2038322010 hasConcept C555283112 @default.
- W2038322010 hasConcept C86339819 @default.
- W2038322010 hasConcept C86803240 @default.
- W2038322010 hasConcept C94966510 @default.
- W2038322010 hasConcept C95444343 @default.
- W2038322010 hasConceptScore W2038322010C102906071 @default.
- W2038322010 hasConceptScore W2038322010C104317684 @default.
- W2038322010 hasConceptScore W2038322010C141231307 @default.
- W2038322010 hasConceptScore W2038322010C159047783 @default.
- W2038322010 hasConceptScore W2038322010C19408993 @default.
- W2038322010 hasConceptScore W2038322010C2778461978 @default.
- W2038322010 hasConceptScore W2038322010C41091548 @default.
- W2038322010 hasConceptScore W2038322010C502942594 @default.
- W2038322010 hasConceptScore W2038322010C54355233 @default.
- W2038322010 hasConceptScore W2038322010C555283112 @default.
- W2038322010 hasConceptScore W2038322010C86339819 @default.
- W2038322010 hasConceptScore W2038322010C86803240 @default.
- W2038322010 hasConceptScore W2038322010C94966510 @default.
- W2038322010 hasConceptScore W2038322010C95444343 @default.
- W2038322010 hasLocation W20383220101 @default.
- W2038322010 hasLocation W20383220102 @default.
- W2038322010 hasLocation W20383220103 @default.
- W2038322010 hasLocation W20383220104 @default.