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• W2038331446 startingPage "383" @default.
• W2038331446 abstract "Recent evidence suggests that the substantia nigra (SN) may be involved in the modification of various experimental epilepsy models. We determined the role of γ-aminobutyric acid (GABA)ergic activity of the SN and the target sites of SN efferents, the pedunculopontine nucleus (PPN) and superior colliculus (SC), in pentylenetetrazol-induced seizures in rats. Bilateral administration of a GABA agonist (muscimol) into the SN significantly reduced seizure severity; its administration into the PPN significantly augmented seizure severity; administration into the SC did not alter the seizure severity. On the other hand, infusion of a GABA antagonist (bicuculline) into the PPN revealed a protective effect against seizures. Our findings indicate that the nigral GABAergic projection to the PPN play an important role in seizure propagation. Thus, PPN neurons may be a possible target site of nigral output modulating seizure propagation." @default.
• W2038331446 created "2016-06-24" @default.
• W2038331446 creator A5001155115 @default.
• W2038331446 creator A5067989882 @default.
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• W2038331446 date "1989-02-01" @default.
• W2038331446 modified "2023-10-03" @default.
• W2038331446 title "The role of the nigrotegmental GABAergic pathway in the propagation of pentylenetetrazol-induced seizures" @default.
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• W2038331446 doi "https://doi.org/10.1016/0006-8993(89)90212-6" @default.
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• W2038331446 hasPublicationYear "1989" @default.
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