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- W2038331836 endingPage "118" @default.
- W2038331836 startingPage "106" @default.
- W2038331836 abstract "Histidine-rich glycoprotein (HRG) is an abundant plasma glycoprotein that has a multidomain structure, interacts with many ligands, and has been shown to regulate a number of important biological processes. HRG ligands include Zn(2+) and haem, tropomyosin, heparin and heparan sulphate, plasminogen, plasmin, fibrinogen, thrombospondin, IgG, FcgammaR and complement. In many cases, the histidine-rich region of the molecule enhances ligand binding following interaction with Zn(2+) or exposure to low pH, conditions associated with sites of tissue injury or tumour growth. The multidomain nature of HRG indicates that it can act as an extracellular adaptor protein, bringing together disparate ligands, particularly on cell surfaces. HRG binds to most cells primarily via heparan sulphate proteoglycans, binding which is also potentiated by elevated free Zn(2+) levels and low pH. Recent reports have shown that HRG can modulate angiogenesis and additional studies have shown that it may regulate other physiological processes such as cell adhesion and migration, fibrinolysis and coagulation, complement activation, immune complex clearance and phagocytosis of apoptotic cells. This review outlines the molecular, structural, biological and clinical properties of HRG as well as describing the role of HRG in various physiological processes." @default.
- W2038331836 created "2016-06-24" @default.
- W2038331836 creator A5025637670 @default.
- W2038331836 creator A5068646165 @default.
- W2038331836 creator A5089817671 @default.
- W2038331836 date "2005-04-01" @default.
- W2038331836 modified "2023-10-03" @default.
- W2038331836 title "Histidine‐rich glycoprotein: A novel adaptor protein in plasma that modulates the immune, vascular and coagulation systems" @default.
- W2038331836 cites W10029901 @default.
- W2038331836 cites W1203214296 @default.
- W2038331836 cites W1428197784 @default.
- W2038331836 cites W1505957065 @default.
- W2038331836 cites W1509088285 @default.
- W2038331836 cites W1509564645 @default.
- W2038331836 cites W1518894724 @default.
- W2038331836 cites W1527418628 @default.
- W2038331836 cites W1536108064 @default.
- W2038331836 cites W1542703728 @default.
- W2038331836 cites W1543388250 @default.
- W2038331836 cites W1549631663 @default.
- W2038331836 cites W1563348198 @default.
- W2038331836 cites W1579668851 @default.
- W2038331836 cites W1585381142 @default.
- W2038331836 cites W1592149136 @default.
- W2038331836 cites W1597312744 @default.
- W2038331836 cites W1861164204 @default.
- W2038331836 cites W1941829554 @default.
- W2038331836 cites W1954547860 @default.
- W2038331836 cites W1966778524 @default.
- W2038331836 cites W1967730199 @default.
- W2038331836 cites W196867063 @default.
- W2038331836 cites W1969450952 @default.
- W2038331836 cites W1970307306 @default.
- W2038331836 cites W1970956968 @default.
- W2038331836 cites W1978400474 @default.
- W2038331836 cites W1979229054 @default.
- W2038331836 cites W1979335925 @default.
- W2038331836 cites W1981073043 @default.
- W2038331836 cites W1982092179 @default.
- W2038331836 cites W1982606309 @default.
- W2038331836 cites W1983826913 @default.
- W2038331836 cites W1984251736 @default.
- W2038331836 cites W1985806579 @default.
- W2038331836 cites W1987268257 @default.
- W2038331836 cites W1987928326 @default.
- W2038331836 cites W1988096950 @default.
- W2038331836 cites W1994813115 @default.
- W2038331836 cites W1997309515 @default.
- W2038331836 cites W1997573520 @default.
- W2038331836 cites W1998330954 @default.
- W2038331836 cites W1999098543 @default.
- W2038331836 cites W1999995708 @default.
- W2038331836 cites W2000056060 @default.
- W2038331836 cites W2005055328 @default.
- W2038331836 cites W2005870919 @default.
- W2038331836 cites W2015627220 @default.
- W2038331836 cites W2016585577 @default.
- W2038331836 cites W2019399271 @default.
- W2038331836 cites W2024560631 @default.
- W2038331836 cites W2024652333 @default.
- W2038331836 cites W2025446407 @default.
- W2038331836 cites W2026503062 @default.
- W2038331836 cites W2028097667 @default.
- W2038331836 cites W2028481131 @default.
- W2038331836 cites W2028670834 @default.
- W2038331836 cites W2029566640 @default.
- W2038331836 cites W2030998749 @default.
- W2038331836 cites W2040469304 @default.
- W2038331836 cites W2040976557 @default.
- W2038331836 cites W2052779192 @default.
- W2038331836 cites W2054534235 @default.
- W2038331836 cites W2055515174 @default.
- W2038331836 cites W2056323994 @default.
- W2038331836 cites W2056598617 @default.
- W2038331836 cites W2058805901 @default.
- W2038331836 cites W2059666020 @default.
- W2038331836 cites W2066409110 @default.
- W2038331836 cites W2068411466 @default.
- W2038331836 cites W2074615019 @default.
- W2038331836 cites W2077609145 @default.
- W2038331836 cites W2079881082 @default.
- W2038331836 cites W2088492889 @default.
- W2038331836 cites W2092378641 @default.
- W2038331836 cites W2095534957 @default.
- W2038331836 cites W2100172797 @default.
- W2038331836 cites W2101796936 @default.
- W2038331836 cites W2118424688 @default.
- W2038331836 cites W2138430027 @default.
- W2038331836 cites W2138877156 @default.
- W2038331836 cites W2143820534 @default.
- W2038331836 cites W2153718410 @default.
- W2038331836 cites W2155318909 @default.
- W2038331836 cites W2157447701 @default.
- W2038331836 cites W2162699516 @default.
- W2038331836 cites W2169829977 @default.
- W2038331836 cites W2169894855 @default.
- W2038331836 cites W2271755970 @default.
- W2038331836 cites W2285126563 @default.