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- W2038341799 abstract "Cis-Dichlorodiamine platinum (cis-Pt). a chemotherapeutic agent used for the treatment of a variety of cancers was found to interfere with the normal clinical uptake of radiogallium. Competitive experiments in which cis-Pt and 67Ga-nitrilotriacetate were incubated with transferrin, demonstrated that no interference of gallium binding to transferrin occurs at this stage. The melanoma tissue culture studies indicated that the uptake of 67Ga-citrate and 67Ga-transferrin was affected only after prolonged preincubation of the cells with cis-Pt. This was confirmed in vivo. Tumor-bearing dogs injected with both 67Ga-transferrin and cis-Pt showed a delayed effect and a reduced uptake of radiogallium in the tumor. These findings suggest that the effect of cis-Pt on gallium uptake is related to the cellular protein synthesis rather than the inhibition of the binding of 67Ga to transferrin." @default.
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- W2038341799 date "1981-01-01" @default.
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- W2038341799 title "Alterations of gallium-67 uptake in tumors by cis-platinum" @default.
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- W2038341799 doi "https://doi.org/10.1016/0047-0740(81)90035-8" @default.
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