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• W2038344262 abstract "No AccessJournal of UrologyTestis1 Oct 2013The Relation between Adult Dark Spermatogonia and Other Parameters of Fertility Potential in Cryptorchid Testes Jorgen Thorup, Kolja Kvist, Erik Clasen-Linde, Bodil Laub Petersen, and Dina Cortes Jorgen ThorupJorgen Thorup Department of Pediatric Surgery, Rigshospitalet, Copenhagen, Denmark Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark More articles by this author , Kolja KvistKolja Kvist Department of Pediatric Surgery, Rigshospitalet, Copenhagen, Denmark More articles by this author , Erik Clasen-LindeErik Clasen-Linde Department of Pathology, Rigshospitalet, Copenhagen, Denmark More articles by this author , Bodil Laub PetersenBodil Laub Petersen Department of Pathology, Rigshospitalet, Copenhagen, Denmark Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark More articles by this author , and Dina CortesDina Cortes Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark Section of Endocrinology, Department of Pediatrics, Hvidovre Hospital, Copenhagen, Denmark More articles by this author View All Author Informationhttps://doi.org/10.1016/j.juro.2013.01.058AboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail Abstract Purpose: The fertility potential of boys with cryptorchidism may be related to the number of adult dark spermatogonia per tubular transverse section in testicular biopsies taken at orchiopexy. Placental-like alkaline phosphatase positive gonocytes in testes within year 1 of life indicate preserved ability for germ cell transformation. We related these parameters to the total number of tubular germ cells and other factors associated with fertility potential. Materials and Methods: The study comprised 89 boys 0.7 to 3 years old (median age 1.8) who underwent bilateral testicular biopsy at bilateral orchiopexy and provided blood samples for gonadotropins and inhibin B. Results: Of 76 boys with adult dark spermatogonia 44 (58%) had a normal mean number of spermatogonia per tubular transverse section compared to 2 of 13 (15%) without adult dark spermatogonia (p <0.05). In the 30 boys with good fertility potential, including a normal mean number of tubular germ cells, and normal gonadotropins and inhibin B, the mean number of adult dark tubular germ cells was 0.081 vs 0.031 in the 38 with low fertility potential, including impaired tubular germ cells and/or low inhibin B but no reactive increase in gonadotropins (p <0.05). In the 21 patients with increased gonadotropins the mean number of adult dark spermatogonia per tubular transverse section was 0.063. Of the 20 boys with normal mean adult dark spermatogonia per tubular transverse section 12 (60%) had good fertility potential, including a normal mean number of tubular germ cells, normal gonadotropins and normal inhibin B, compared to only 18 of 69 (26%) with an impaired mean number of adult dark spermatogonia per tubular transverse section (p <0.05). Of 46 boys with a normal mean number of tubular germ cells 26 (57%) had placental-like alkaline phosphatase positive cells compared to 14 of 43 (33%) with a decreased mean number of tubular germ cells (p <0.05). Conclusions: The number of placental-like alkaline phosphatase positive gonocytes and adult dark spermatogonia per tubular transverse section are important parameters related to the fertility potential of boys with cryptorchid testes. References 1 : Bilateral undescended testes classified according to preoperative and postoperative status of gonadotropins and inhibin B in relation to testicular histopathology at bilateral orchiopexy in infant boys. J Urol2012; 188: 1436. Link, Google Scholar 2 : Cryptorchidism: aspects of pathogenesis, histology and treatment. Scand J Urol Nephrol, suppl.1998; 32: 1. Google Scholar 3 : Testicular histology related to fertility outcome and postpubertal hormone status in cryptorchidism. Klin Pädiatr2008; 220: 302. 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Google Scholar 17 : Testis histopathology in boys with cryptorchidism correlates with future fertility potential. J Urol2003; 169: 659. Link, Google Scholar 18 : Undescended testis histology correlation with adult hormone levels and semen analysis. J Urol2012; 188: 1429. Link, Google Scholar 19 : Editorial comment: Undescended testis histology correlation with adult hormone levels and semen analysis. J Urol2012; 188: 1435. Link, Google Scholar 20 : Increase in testicular temperature in case of cryptorchidism in boys. Fertil Steril1993; 59: 1319. Google Scholar © 2013 by American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byHildorf S, Clasen-Linde E, Cortes D, Fossum M and Thorup J (2019) Fertility Potential is Compromised in 20% to 25% of Boys with Nonsyndromic Cryptorchidism despite Orchiopexy within the First Year of LifeJournal of Urology, VOL. 203, NO. 4, (832-840), Online publication date: 1-Apr-2020.Braga L and Lorenzo A (2018) The Changing Elaboration of Inhibin B in Patients with Unilateral Testicular Maldescent vs Vanished TestisJournal of Urology, VOL. 193, NO. 5, (1465-1466), Online publication date: 1-May-2015.Li R, Thorup J, Sun C, Cortes D, Southwell B and Hutson J (2018) Immunofluorescent Analysis of Testicular Biopsies with Germ Cell and Sertoli Cell Markers Shows Significant MVH Negative Germ Cell Depletion with Older Age at OrchiopexyJournal of Urology, VOL. 191, NO. 2, (458-464), Online publication date: 1-Feb-2014.Pastuszak A and Lipshultz L (2018) AUA Guideline on the Diagnosis and Treatment of CryptorchidismJournal of Urology, VOL. 192, NO. 2, (346-349), Online publication date: 1-Aug-2014. Volume 190Issue 4SOctober 2013Page: 1566-1571 Advertisement Copyright & Permissions© 2013 by American Urological Association Education and Research, Inc.Keywordsgonadotropinsinhibin Bcryptorchidismtestisinfertility, maleMetricsAuthor Information Jorgen Thorup Department of Pediatric Surgery, Rigshospitalet, Copenhagen, Denmark Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark More articles by this author Kolja Kvist Department of Pediatric Surgery, Rigshospitalet, Copenhagen, Denmark More articles by this author Erik Clasen-Linde Department of Pathology, Rigshospitalet, Copenhagen, Denmark More articles by this author Bodil Laub Petersen Department of Pathology, Rigshospitalet, Copenhagen, Denmark Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark More articles by this author Dina Cortes Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark Section of Endocrinology, Department of Pediatrics, Hvidovre Hospital, Copenhagen, Denmark More articles by this author Expand All Advertisement PDF downloadLoading ..." @default.
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