FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038348425> ?p ?o ?g. }

• W2038348425 endingPage "2238" @default.
• W2038348425 startingPage "2238" @default.
• W2038348425 abstract "Purpose To investigate the elimination rate of voriconazole after intravitreal injection in rabbits.Intravitreal injections of 35 microg/0.1 mL voriconazole were administered to rabbits. Vitreous and aqueous humor levels of voriconazole were determined at selected time intervals (1, 2, 4, 8, 16, 24, and 48 hours), and the in vitreous half-life was calculated. Four to six eyes per time point after injection were enucleated and immediately stored at -80 degrees C. Aqueous humor samples were withdrawn before enucleation, and vitreous samples were obtained from ocular dissection and isolation at various time intervals. Voriconazole concentrations in vitreous and aqueous humor were assayed with high-performance liquid chromatography (HPLC).The concentration of intravitreal voriconazole at various time points exhibited exponential decay with a half-life of 2.5 hours. The mean vitreous concentration was 18.912 +/- 2.058 microg/mL 1 hour after intravitreal injection; this declined to 0.292 +/- 0.090 microg/mL at 16 hours. The mean aqueous concentration was much lower and showed a decline from 0.240 +/- 0.051 microg/mL at 1 hour to undetectable levels 8 hours after injection.Vitreous concentrations achieved during the first 8 hours were greater than the previously reported minimum inhibitory concentrations (MICs) of organisms most involved in fungal endophthalmitis. A rapid decline of intravitreal concentration suggests that supplementation of intraocular voriconazole to maintain therapeutic levels may therefore be required in clinical settings. Further studies are needed to determine the elimination rate of voriconazole after intravitreal injection in humans." @default.
• W2038348425 created "2016-06-24" @default.
• W2038348425 creator A5029231112 @default.
• W2038348425 creator A5034106039 @default.
• W2038348425 creator A5040292118 @default.
• W2038348425 creator A5045092574 @default.
• W2038348425 creator A5065578298 @default.
• W2038348425 creator A5086510758 @default.
• W2038348425 creator A5090812771 @default.
• W2038348425 date "2007-05-01" @default.
• W2038348425 modified "2023-09-30" @default.
• W2038348425 title "Clearance of Intravitreal Voriconazole" @default.
• W2038348425 cites W14220875 @default.
• W2038348425 cites W1558549775 @default.
• W2038348425 cites W1565636659 @default.
• W2038348425 cites W174172419 @default.
• W2038348425 cites W179618484 @default.
• W2038348425 cites W1965705300 @default.
• W2038348425 cites W1968169609 @default.
• W2038348425 cites W1979584213 @default.
• W2038348425 cites W1985104966 @default.
• W2038348425 cites W1988195179 @default.
• W2038348425 cites W1998506847 @default.
• W2038348425 cites W1998840608 @default.
• W2038348425 cites W1998968802 @default.
• W2038348425 cites W2007887375 @default.
• W2038348425 cites W2035626868 @default.
• W2038348425 cites W2040934856 @default.
• W2038348425 cites W2049686946 @default.
• W2038348425 cites W2062329228 @default.
• W2038348425 cites W2063971103 @default.
• W2038348425 cites W2074477744 @default.
• W2038348425 cites W2084979997 @default.
• W2038348425 cites W2087548480 @default.
• W2038348425 cites W2098256719 @default.
• W2038348425 cites W2119064707 @default.
• W2038348425 cites W2121842516 @default.
• W2038348425 cites W2136082168 @default.
• W2038348425 cites W2142854079 @default.
• W2038348425 cites W2164996340 @default.
• W2038348425 cites W39426453 @default.
• W2038348425 cites W42005249 @default.
• W2038348425 cites W67339826 @default.
• W2038348425 cites W2588770874 @default.
• W2038348425 doi "https://doi.org/10.1167/iovs.06-1362" @default.
• W2038348425 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17460285" @default.
• W2038348425 hasPublicationYear "2007" @default.
• W2038348425 type Work @default.
• W2038348425 sameAs 2038348425 @default.
• W2038348425 citedByCount "59" @default.
• W2038348425 countsByYear W20383484252012 @default.
• W2038348425 countsByYear W20383484252013 @default.
• W2038348425 countsByYear W20383484252014 @default.
• W2038348425 countsByYear W20383484252015 @default.
• W2038348425 countsByYear W20383484252016 @default.
• W2038348425 countsByYear W20383484252017 @default.
• W2038348425 countsByYear W20383484252018 @default.
• W2038348425 countsByYear W20383484252019 @default.
• W2038348425 countsByYear W20383484252020 @default.
• W2038348425 countsByYear W20383484252021 @default.
• W2038348425 countsByYear W20383484252022 @default.
• W2038348425 countsByYear W20383484252023 @default.
• W2038348425 crossrefType "journal-article" @default.
• W2038348425 hasAuthorship W2038348425A5029231112 @default.
• W2038348425 hasAuthorship W2038348425A5034106039 @default.
• W2038348425 hasAuthorship W2038348425A5040292118 @default.
• W2038348425 hasAuthorship W2038348425A5045092574 @default.
• W2038348425 hasAuthorship W2038348425A5065578298 @default.
• W2038348425 hasAuthorship W2038348425A5086510758 @default.
• W2038348425 hasAuthorship W2038348425A5090812771 @default.
• W2038348425 hasBestOaLocation W20383484251 @default.
• W2038348425 hasConcept C112705442 @default.
• W2038348425 hasConcept C118487528 @default.
• W2038348425 hasConcept C141071460 @default.
• W2038348425 hasConcept C16005928 @default.
• W2038348425 hasConcept C176947019 @default.
• W2038348425 hasConcept C185592680 @default.
• W2038348425 hasConcept C188261085 @default.
• W2038348425 hasConcept C2777235844 @default.
• W2038348425 hasConcept C2779548794 @default.
• W2038348425 hasConcept C2780690907 @default.
• W2038348425 hasConcept C2993390227 @default.
• W2038348425 hasConcept C3941253 @default.
• W2038348425 hasConcept C42219234 @default.
• W2038348425 hasConcept C43617362 @default.
• W2038348425 hasConcept C501593827 @default.
• W2038348425 hasConcept C55493867 @default.
• W2038348425 hasConcept C71924100 @default.
• W2038348425 hasConcept C98274493 @default.
• W2038348425 hasConceptScore W2038348425C112705442 @default.
• W2038348425 hasConceptScore W2038348425C118487528 @default.
• W2038348425 hasConceptScore W2038348425C141071460 @default.
• W2038348425 hasConceptScore W2038348425C16005928 @default.
• W2038348425 hasConceptScore W2038348425C176947019 @default.
• W2038348425 hasConceptScore W2038348425C185592680 @default.
• W2038348425 hasConceptScore W2038348425C188261085 @default.
• W2038348425 hasConceptScore W2038348425C2777235844 @default.
• W2038348425 hasConceptScore W2038348425C2779548794 @default.

• next