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• W2038349747 endingPage "R139" @default.
• W2038349747 startingPage "R131" @default.
• W2038349747 abstract "In female mammals, the dosage difference in X-linked genes between XX females and XY males is compensated for by inactivating one of the two X chromosomes during early development. Since the discovery of the X inactive-specific transcript ( XIST ) gene in humans and its subsequent isolation of the mouse homolog, Xist , in the early 1990s, the molecular basis of X chromosome inactivation (X-inactivation) has been more fully elucidated using genetically manipulated mouse embryos and embryonic stem cells. Studies on X-inactivation in other mammals, although limited when compared with those in the mice, have revealed that, while their inactive X chromosome shares many features with those in the mice, there are marked differences in not only some epigenetic modifications of the inactive X chromosome but also when and how X-inactivation is initiated during early embryonic development. Such differences raise the issue about what extent of the molecular basis of X-inactivation in the mice is commonly shared among others. Recognizing similarities and differences in X-inactivation among mammals may provide further insight into our understanding of not only the evolutionary but also the molecular aspects for the mechanism of X-inactivation. Here, we reviewed species-specific differences in X-inactivation and discussed what these differences may reveal." @default.
• W2038349747 created "2016-06-24" @default.
• W2038349747 creator A5080018476 @default.
• W2038349747 creator A5090601814 @default.
• W2038349747 date "2013-10-01" @default.
• W2038349747 modified "2023-09-23" @default.
• W2038349747 title "Species-specific differences in X chromosome inactivation in mammals" @default.
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• W2038349747 doi "https://doi.org/10.1530/rep-13-0173" @default.
• W2038349747 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23847260" @default.
• W2038349747 hasPublicationYear "2013" @default.
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