Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038367060> ?p ?o ?g. }
- W2038367060 endingPage "16" @default.
- W2038367060 startingPage "1" @default.
- W2038367060 abstract "Chondrogenesis is known to be regulated by calcium-dependent signalling pathways in which temporal aspects of calcium homeostasis are of key importance. We aimed to better characterise calcium influx and release functions with respect to rapid calcium oscillations in cells of chondrifying chicken high density cultures. We found that differentiating chondrocytes express the α1 subunit of voltage-operated calcium channels (VOCCs) at both mRNA and protein levels, and that these ion channels play important roles in generating Ca2+ influx for oscillations as nifedipine interfered with repetitive calcium transients. Furthermore, VOCC blockade abrogated chondrogenesis and almost completely blocked cell proliferation. The contribution of internal Ca2+ stores via store-operated Ca2+ entry (SOCE) seems to be indispensable to both Ca2+ oscillations and chondrogenesis. Moreover, this is the first study to show the functional expression of STIM1/STIM2 and Orai1, molecules that orchestrate SOCE, in chondrogenic cells. Inhibition of SOCE combined with ER calcium store depletion abolished differentiation and severely diminished proliferation, suggesting the important role of internal pools in calcium homeostasis of differentiating chondrocytes. Finally, we present an integrated model for the regulation of calcium oscillations of differentiating chondrocytes that may have important implications for studies of chondrogenesis induced in various stem cell populations." @default.
- W2038367060 created "2016-06-24" @default.
- W2038367060 creator A5015395421 @default.
- W2038367060 creator A5043600016 @default.
- W2038367060 creator A5046335584 @default.
- W2038367060 creator A5061621955 @default.
- W2038367060 creator A5076130380 @default.
- W2038367060 creator A5080160190 @default.
- W2038367060 creator A5084498555 @default.
- W2038367060 creator A5085852829 @default.
- W2038367060 creator A5089298188 @default.
- W2038367060 date "2013-07-01" @default.
- W2038367060 modified "2023-10-14" @default.
- W2038367060 title "Store-operated calcium entry and calcium influx via voltage-operated calcium channels regulate intracellular calcium oscillations in chondrogenic cells" @default.
- W2038367060 cites W1554417971 @default.
- W2038367060 cites W1554446171 @default.
- W2038367060 cites W1599277155 @default.
- W2038367060 cites W1972209517 @default.
- W2038367060 cites W1979475985 @default.
- W2038367060 cites W1980727894 @default.
- W2038367060 cites W1983449340 @default.
- W2038367060 cites W1986216505 @default.
- W2038367060 cites W1988005968 @default.
- W2038367060 cites W1989573171 @default.
- W2038367060 cites W1991551641 @default.
- W2038367060 cites W1995829436 @default.
- W2038367060 cites W1996778890 @default.
- W2038367060 cites W1997113614 @default.
- W2038367060 cites W2003142024 @default.
- W2038367060 cites W2009809074 @default.
- W2038367060 cites W2010613687 @default.
- W2038367060 cites W2011454589 @default.
- W2038367060 cites W2017367230 @default.
- W2038367060 cites W2022359639 @default.
- W2038367060 cites W2023070796 @default.
- W2038367060 cites W2024227894 @default.
- W2038367060 cites W2035372385 @default.
- W2038367060 cites W2036692331 @default.
- W2038367060 cites W2039809463 @default.
- W2038367060 cites W2040043194 @default.
- W2038367060 cites W2043052471 @default.
- W2038367060 cites W2044474278 @default.
- W2038367060 cites W2046299697 @default.
- W2038367060 cites W2050596084 @default.
- W2038367060 cites W2051586252 @default.
- W2038367060 cites W2054670640 @default.
- W2038367060 cites W2054723193 @default.
- W2038367060 cites W2057232267 @default.
- W2038367060 cites W2057913715 @default.
- W2038367060 cites W2066754391 @default.
- W2038367060 cites W2067453045 @default.
- W2038367060 cites W2067947829 @default.
- W2038367060 cites W2074123147 @default.
- W2038367060 cites W2075345875 @default.
- W2038367060 cites W2082940711 @default.
- W2038367060 cites W2084435232 @default.
- W2038367060 cites W2084619475 @default.
- W2038367060 cites W2086046729 @default.
- W2038367060 cites W2086261222 @default.
- W2038367060 cites W2092558582 @default.
- W2038367060 cites W2094649883 @default.
- W2038367060 cites W2095049732 @default.
- W2038367060 cites W2108434819 @default.
- W2038367060 cites W2120738384 @default.
- W2038367060 cites W2122883560 @default.
- W2038367060 cites W2135011583 @default.
- W2038367060 cites W2136623476 @default.
- W2038367060 cites W2138094668 @default.
- W2038367060 cites W2138173661 @default.
- W2038367060 cites W2140556121 @default.
- W2038367060 cites W2141260882 @default.
- W2038367060 cites W2144517964 @default.
- W2038367060 cites W2157078498 @default.
- W2038367060 cites W2158560699 @default.
- W2038367060 cites W2169731710 @default.
- W2038367060 cites W2407283280 @default.
- W2038367060 cites W2412640143 @default.
- W2038367060 cites W4211040987 @default.
- W2038367060 cites W4249759827 @default.
- W2038367060 cites W4376453153 @default.
- W2038367060 doi "https://doi.org/10.1016/j.ceca.2013.03.003" @default.
- W2038367060 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23664335" @default.
- W2038367060 hasPublicationYear "2013" @default.
- W2038367060 type Work @default.
- W2038367060 sameAs 2038367060 @default.
- W2038367060 citedByCount "58" @default.
- W2038367060 countsByYear W20383670602013 @default.
- W2038367060 countsByYear W20383670602014 @default.
- W2038367060 countsByYear W20383670602015 @default.
- W2038367060 countsByYear W20383670602016 @default.
- W2038367060 countsByYear W20383670602017 @default.
- W2038367060 countsByYear W20383670602018 @default.
- W2038367060 countsByYear W20383670602019 @default.
- W2038367060 countsByYear W20383670602020 @default.
- W2038367060 countsByYear W20383670602021 @default.
- W2038367060 countsByYear W20383670602022 @default.
- W2038367060 countsByYear W20383670602023 @default.
- W2038367060 crossrefType "journal-article" @default.