FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038371180> ?p ?o ?g. }

• W2038371180 endingPage "554" @default.
• W2038371180 startingPage "546" @default.
• W2038371180 abstract "Ca(2+)-induced enzyme secretion in the exocrine pancreas is not completely understood. We have proposed that Ca(2+)-induced enzyme secretion in the exocrine pancreas involves activation of ion conductances in the membrane of zymogen granules (ZG). Here we have identified a Ca(2+)-activated anion conductance in rat pancreatic ZG membranes (ZGM). Ca(2+) (2.5-50 microM) increased the conductance for I(-), NO(3)(-), Br(-), or HCO(3)(-), but not for Cl(-), as determined by the rate of valinomycin-induced osmotic lysis of ZG suspended in isotonic K(+)-salts. 4,4'-Diisothiocyanatodihydrostilbene-2,2'-disulfonate (100 microM) or 25 microM dithiothreitol strongly inhibited Ca(2+)-dependent lysis. The permeability sequence, Ca(2+) dependence, and inhibitor sensitivity of ZG anion conductance are reminiscent of a family of epithelial Ca(2+)-activated anion channels (CLCA). CLCA expression was confirmed by RT-PCR with rat pancreatic mRNA and mouse CLCA1 primers. A PCR product (580bp) exhibited 81%, 77%, and 57% amino acid similarity to the three mouse isoforms mCLCA-1, -2, and -3 (mgob-5), respectively. Antibodies against bovine tracheal CLCA1 showed CLCA expression in ZGM by immunoblotting, immunoperoxidase light microscopy, and immunogold labeling. These findings suggest that a CLCA-related protein could account for the Ca(2+)-activated HCO(3)(-) conductance of rat pancreatic ZGM and contribute to hormone-stimulated enzyme secretion." @default.
• W2038371180 created "2016-06-24" @default.
• W2038371180 creator A5008621245 @default.
• W2038371180 creator A5030327846 @default.
• W2038371180 creator A5036056918 @default.
• W2038371180 creator A5065211041 @default.
• W2038371180 date "2003-01-01" @default.
• W2038371180 modified "2023-09-25" @default.
• W2038371180 title "Relationship between a HCO3−-permeable conductance and a CLCA protein from rat pancreatic zymogen granules" @default.
• W2038371180 cites W1513511290 @default.
• W2038371180 cites W1522298610 @default.
• W2038371180 cites W1525330575 @default.
• W2038371180 cites W1963979663 @default.
• W2038371180 cites W1965068448 @default.
• W2038371180 cites W1974293207 @default.
• W2038371180 cites W1991820226 @default.
• W2038371180 cites W1995066489 @default.
• W2038371180 cites W1996818912 @default.
• W2038371180 cites W2003425871 @default.
• W2038371180 cites W2016695945 @default.
• W2038371180 cites W2025567730 @default.
• W2038371180 cites W2026290001 @default.
• W2038371180 cites W2033441411 @default.
• W2038371180 cites W2033490823 @default.
• W2038371180 cites W2038973325 @default.
• W2038371180 cites W2047377966 @default.
• W2038371180 cites W2047658829 @default.
• W2038371180 cites W2059232582 @default.
• W2038371180 cites W2066030442 @default.
• W2038371180 cites W2071315089 @default.
• W2038371180 cites W2078075514 @default.
• W2038371180 cites W2087132310 @default.
• W2038371180 cites W2092229320 @default.
• W2038371180 cites W2092561505 @default.
• W2038371180 cites W2098660493 @default.
• W2038371180 cites W2106519810 @default.
• W2038371180 cites W2121576595 @default.
• W2038371180 cites W2124663797 @default.
• W2038371180 cites W2126153001 @default.
• W2038371180 cites W2130568339 @default.
• W2038371180 cites W2131653836 @default.
• W2038371180 cites W2141255220 @default.
• W2038371180 cites W2142606936 @default.
• W2038371180 cites W2152551546 @default.
• W2038371180 cites W2160440316 @default.
• W2038371180 cites W2164321065 @default.
• W2038371180 cites W2165257594 @default.
• W2038371180 cites W2187516635 @default.
• W2038371180 cites W2221736702 @default.
• W2038371180 cites W2262858698 @default.
• W2038371180 cites W2315143177 @default.
• W2038371180 cites W2344818406 @default.
• W2038371180 cites W2415114169 @default.
• W2038371180 cites W2415252448 @default.
• W2038371180 cites W384010788 @default.
• W2038371180 cites W4230105298 @default.
• W2038371180 cites W4293247451 @default.
• W2038371180 doi "https://doi.org/10.1016/s0006-291x(02)02871-1" @default.
• W2038371180 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12504118" @default.
• W2038371180 hasPublicationYear "2003" @default.
• W2038371180 type Work @default.
• W2038371180 sameAs 2038371180 @default.
• W2038371180 citedByCount "16" @default.
• W2038371180 countsByYear W20383711802012 @default.
• W2038371180 countsByYear W20383711802013 @default.
• W2038371180 countsByYear W20383711802014 @default.
• W2038371180 countsByYear W20383711802015 @default.
• W2038371180 crossrefType "journal-article" @default.
• W2038371180 hasAuthorship W2038371180A5008621245 @default.
• W2038371180 hasAuthorship W2038371180A5030327846 @default.
• W2038371180 hasAuthorship W2038371180A5036056918 @default.
• W2038371180 hasAuthorship W2038371180A5065211041 @default.
• W2038371180 hasConcept C145822097 @default.
• W2038371180 hasConcept C153911025 @default.
• W2038371180 hasConcept C181199279 @default.
• W2038371180 hasConcept C185592680 @default.
• W2038371180 hasConcept C2777824588 @default.
• W2038371180 hasConcept C2779700409 @default.
• W2038371180 hasConcept C55493867 @default.
• W2038371180 hasConcept C86803240 @default.
• W2038371180 hasConceptScore W2038371180C145822097 @default.
• W2038371180 hasConceptScore W2038371180C153911025 @default.
• W2038371180 hasConceptScore W2038371180C181199279 @default.
• W2038371180 hasConceptScore W2038371180C185592680 @default.
• W2038371180 hasConceptScore W2038371180C2777824588 @default.
• W2038371180 hasConceptScore W2038371180C2779700409 @default.
• W2038371180 hasConceptScore W2038371180C55493867 @default.
• W2038371180 hasConceptScore W2038371180C86803240 @default.
• W2038371180 hasIssue "2" @default.
• W2038371180 hasLocation W20383711801 @default.
• W2038371180 hasLocation W20383711802 @default.
• W2038371180 hasOpenAccess W2038371180 @default.
• W2038371180 hasPrimaryLocation W20383711801 @default.
• W2038371180 hasRelatedWork W1970294642 @default.
• W2038371180 hasRelatedWork W1979518023 @default.
• W2038371180 hasRelatedWork W2011917699 @default.
• W2038371180 hasRelatedWork W2013246356 @default.
• W2038371180 hasRelatedWork W2021332114 @default.

• next