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• W2038385761 abstract "Ciliated protozoa have two functionally distinct nuclei, a micronucleus (MIC) and a macronucleus (MAC) [1Karrer K.M. Tetrahymena genetics: Two nuclei are better than one.Methods Cell Biol. 2000; 62: 127-186Crossref PubMed Google Scholar]. These two nuclei are distinct in size, transcriptional activity, and division cycle control, proceeding with cycles of DNA replication and nuclear division at different times within the same cell [2Gorovsky M.A. Macro- and micronuclei of Tetrahymena pyriformis: A model system for studying the structure and function of eukaryotic nuclei.J. Protozool. 1973; 20: 19-25Crossref PubMed Scopus (111) Google Scholar, 3Frankel J. Cell biology of Tetrahymena thermophila.Methods Cell Biol. 2000; 62: 27-125Crossref PubMed Google Scholar]. The structural basis generating functionally distinct nuclei remains unknown. Here, we show that, in Tetrahymena thermophila, the nuclear pore complexes (NPCs) of MIC and MAC are composed of different sets of nucleoporins. Among the 13 nucleoporins identified, Nup98 homologs were of interest because two out of the four homologs were localized exclusively in the MAC and the other two were localized exclusively in the MIC. The two MAC-localizing Nup98s contain repeats of GLFG [4Powers M.A. Forbes D.J. Dahlberg J.E. Lund E. The vertebrate GLFG nucleoporin, Nup98, is an essential component of multiple RNA export pathways.J. Cell Biol. 1997; 136: 241-250Crossref PubMed Scopus (171) Google Scholar]. In contrast, the two MIC-localizing Nup98s lack the GLFG repeats and instead contain a novel repeat signature of NIFN. Ectopic expression of a chimeric MIC-localizing Nup98 homolog bearing GLFG repeats obstructed the nuclear accumulation of MIC-specific nuclear proteins, and expression of a chimeric MAC-localizing Nup98 homolog bearing NIFN repeats obstructed the nuclear accumulation of MAC-specific nuclear proteins. These results suggest that Nup98s act as a barrier to misdirected localization of nucleus-specific proteins. Our findings provide the first evidence that the NPC contributes to nucleus-selective transport in ciliates." @default.
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• W2038385761 date "2009-05-01" @default.
• W2038385761 modified "2023-10-14" @default.
• W2038385761 title "Two Distinct Repeat Sequences of Nup98 Nucleoporins Characterize Dual Nuclei in the Binucleated Ciliate Tetrahymena" @default.
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• W2038385761 doi "https://doi.org/10.1016/j.cub.2009.03.055" @default.
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