Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038388311> ?p ?o ?g. }
Showing items 1 to 97 of
97
with 100 items per page.
- W2038388311 endingPage "257" @default.
- W2038388311 startingPage "251" @default.
- W2038388311 abstract "Vulnerability to relapse is a central issue in the biology of schizophrenia. The common neural mechanisms underlying such vulnerability can be studied using the experimental model of behavioral sensitization induced by repeated administration of low doses of methamphetamine (MAP) to rodents. This review summarizes a series of behavioral and neurochemical studies on MAP-induced behavioral sensitization from the viewpoint that the mechanisms involved in initiation (or development) of psychotic symptoms and their expression differ. The initiation of behavioral sensitization to MAP in rats requires stimulation of dopaminergic neurons, and can be blocked by SCH 23390 (a dopamine D1-receptor antagonist) and BMY 14802 (a sigma-receptor antagonist). The expression of behavioral sensitization induced by subchronic MAP pretreatment takes several forms. First, dopamine release from the cerebral dopaminergic neuron terminal containing areas in response to either to rechallenge with MAP or cocaine, or evoked by intrastriatal ouabain infusion is enhanced. Second, the behavioral responses to dopamine D2- and sigma-receptor agonists are augmented. A third form involves changes indicative of transsynaptic neural circuits, such as increased numbers of D1 receptors in the substantia nigra pars reticulata, enhanced electrophysiological responses to D1 receptor activation, the putative role of excitatory amino acid receptors and interchangeability of MAP and stress. Although MAP-induced behavioral sensitization in rodents serves as a useful animal model, the elucidation of the mechanisms involved in the vulnerability of patients with schizophrenia to relapse of psychotic episodes requires further study." @default.
- W2038388311 created "2016-06-24" @default.
- W2038388311 creator A5009599515 @default.
- W2038388311 creator A5028999046 @default.
- W2038388311 creator A5053000996 @default.
- W2038388311 creator A5085739497 @default.
- W2038388311 date "1994-06-01" @default.
- W2038388311 modified "2023-10-03" @default.
- W2038388311 title "Methamphetamine-induced behavioral sensitization and its implications for relapse of schizophrenia" @default.
- W2038388311 cites W1964308449 @default.
- W2038388311 cites W1968889342 @default.
- W2038388311 cites W1980695662 @default.
- W2038388311 cites W1985113861 @default.
- W2038388311 cites W1987604732 @default.
- W2038388311 cites W1992735948 @default.
- W2038388311 cites W1996751433 @default.
- W2038388311 cites W1997540813 @default.
- W2038388311 cites W2009243814 @default.
- W2038388311 cites W2023154661 @default.
- W2038388311 cites W2023900408 @default.
- W2038388311 cites W2035611467 @default.
- W2038388311 cites W2036260773 @default.
- W2038388311 cites W2039323107 @default.
- W2038388311 cites W2039462402 @default.
- W2038388311 cites W2066105521 @default.
- W2038388311 cites W2090959420 @default.
- W2038388311 cites W2100321683 @default.
- W2038388311 cites W4296219707 @default.
- W2038388311 doi "https://doi.org/10.1016/0920-9964(94)90035-3" @default.
- W2038388311 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8054317" @default.
- W2038388311 hasPublicationYear "1994" @default.
- W2038388311 type Work @default.
- W2038388311 sameAs 2038388311 @default.
- W2038388311 citedByCount "66" @default.
- W2038388311 countsByYear W20383883112013 @default.
- W2038388311 countsByYear W20383883112014 @default.
- W2038388311 countsByYear W20383883112015 @default.
- W2038388311 countsByYear W20383883112016 @default.
- W2038388311 countsByYear W20383883112018 @default.
- W2038388311 countsByYear W20383883112019 @default.
- W2038388311 countsByYear W20383883112020 @default.
- W2038388311 countsByYear W20383883112021 @default.
- W2038388311 countsByYear W20383883112022 @default.
- W2038388311 countsByYear W20383883112023 @default.
- W2038388311 crossrefType "journal-article" @default.
- W2038388311 hasAuthorship W2038388311A5009599515 @default.
- W2038388311 hasAuthorship W2038388311A5028999046 @default.
- W2038388311 hasAuthorship W2038388311A5053000996 @default.
- W2038388311 hasAuthorship W2038388311A5085739497 @default.
- W2038388311 hasConcept C118552586 @default.
- W2038388311 hasConcept C120750228 @default.
- W2038388311 hasConcept C137183658 @default.
- W2038388311 hasConcept C15744967 @default.
- W2038388311 hasConcept C169760540 @default.
- W2038388311 hasConcept C25876315 @default.
- W2038388311 hasConcept C2776217527 @default.
- W2038388311 hasConcept C2776412080 @default.
- W2038388311 hasConcept C2780376393 @default.
- W2038388311 hasConcept C2780948874 @default.
- W2038388311 hasConcept C513476851 @default.
- W2038388311 hasConcept C71924100 @default.
- W2038388311 hasConcept C98274493 @default.
- W2038388311 hasConceptScore W2038388311C118552586 @default.
- W2038388311 hasConceptScore W2038388311C120750228 @default.
- W2038388311 hasConceptScore W2038388311C137183658 @default.
- W2038388311 hasConceptScore W2038388311C15744967 @default.
- W2038388311 hasConceptScore W2038388311C169760540 @default.
- W2038388311 hasConceptScore W2038388311C25876315 @default.
- W2038388311 hasConceptScore W2038388311C2776217527 @default.
- W2038388311 hasConceptScore W2038388311C2776412080 @default.
- W2038388311 hasConceptScore W2038388311C2780376393 @default.
- W2038388311 hasConceptScore W2038388311C2780948874 @default.
- W2038388311 hasConceptScore W2038388311C513476851 @default.
- W2038388311 hasConceptScore W2038388311C71924100 @default.
- W2038388311 hasConceptScore W2038388311C98274493 @default.
- W2038388311 hasIssue "3" @default.
- W2038388311 hasLocation W20383883111 @default.
- W2038388311 hasLocation W20383883112 @default.
- W2038388311 hasOpenAccess W2038388311 @default.
- W2038388311 hasPrimaryLocation W20383883111 @default.
- W2038388311 hasRelatedWork W1983138582 @default.
- W2038388311 hasRelatedWork W2067147530 @default.
- W2038388311 hasRelatedWork W2083313100 @default.
- W2038388311 hasRelatedWork W2091996505 @default.
- W2038388311 hasRelatedWork W2159377548 @default.
- W2038388311 hasRelatedWork W2416699510 @default.
- W2038388311 hasRelatedWork W2419558231 @default.
- W2038388311 hasRelatedWork W2463293113 @default.
- W2038388311 hasRelatedWork W2588268045 @default.
- W2038388311 hasRelatedWork W4293586768 @default.
- W2038388311 hasVolume "12" @default.
- W2038388311 isParatext "false" @default.
- W2038388311 isRetracted "false" @default.
- W2038388311 magId "2038388311" @default.
- W2038388311 workType "article" @default.