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- W2038395323 endingPage "2456" @default.
- W2038395323 startingPage "2456" @default.
- W2038395323 abstract "The aim of this thesis is to model the impact (dosimetric and radiobiological) of prostate radiotherapy treatment uncertainties and techniques for displaying potential dose errors. A Monte Carlo code is written to simulate both the treatment planning and delivery phases. Distributions of systematic organ motion, systematic positioning error, random organ motion, random positioning error, and interpatient cell sensitivity are taken from the literature. These distributions are used to sample the position and size of the prostate and rectum at each fraction of treatment. Dose to organ voxels are assigned from precalculated dose distributions (four‐field box using 6 MV photons with margins around the clinical target volume of 0.5, 1.0, and 1.5 cm). In particular, the poor estimation of prostate mean position from one planning CT series is investigated and shown to introduce large dose uncertainty. A convolution kernel is suggested that considers multiple pre‐treatment CT scans to better estimate mean prostate position. The radiobiological impact of the treatment uncertainties is evaluated in terms of tumor control probability for prostate, normal tissue complication probability for rectal bleeding and uncomplicated tumor control probability using established models. Local prostate control is highly sensitive to treatment uncertainties with inadequate margin size and to interpatient radiosensitivity. Rectal bleeding is more sensitive to margin size than to deformation. A number of ways to display the dosimetric uncertainty are presented. The display tools proposed allow the planner to consider potential variations in dose visually and may assist with margin size considerations." @default.
- W2038395323 created "2016-06-24" @default.
- W2038395323 creator A5033645190 @default.
- W2038395323 date "2002-10-01" @default.
- W2038395323 modified "2023-09-26" @default.
- W2038395323 title "Modeling the impact of treatment uncertainties in radiotherapy" @default.
- W2038395323 cites W1840534470 @default.
- W2038395323 cites W1925962934 @default.
- W2038395323 cites W1966604596 @default.
- W2038395323 cites W1968180137 @default.
- W2038395323 cites W1971264711 @default.
- W2038395323 cites W1971747664 @default.
- W2038395323 cites W1972139858 @default.
- W2038395323 cites W1975292370 @default.
- W2038395323 cites W1975511020 @default.
- W2038395323 cites W1975664090 @default.
- W2038395323 cites W1976592695 @default.
- W2038395323 cites W1976996553 @default.
- W2038395323 cites W1978124163 @default.
- W2038395323 cites W1979620059 @default.
- W2038395323 cites W1979780461 @default.
- W2038395323 cites W1979914233 @default.
- W2038395323 cites W1980103504 @default.
- W2038395323 cites W1980856643 @default.
- W2038395323 cites W1981712893 @default.
- W2038395323 cites W1981870695 @default.
- W2038395323 cites W1982608710 @default.
- W2038395323 cites W1983409544 @default.
- W2038395323 cites W1983945844 @default.
- W2038395323 cites W1984170044 @default.
- W2038395323 cites W1984249139 @default.
- W2038395323 cites W1984742825 @default.
- W2038395323 cites W1984976240 @default.
- W2038395323 cites W1986019734 @default.
- W2038395323 cites W1990510898 @default.
- W2038395323 cites W1996486348 @default.
- W2038395323 cites W1997593182 @default.
- W2038395323 cites W1999248274 @default.
- W2038395323 cites W2002022267 @default.
- W2038395323 cites W2004006404 @default.
- W2038395323 cites W2004965124 @default.
- W2038395323 cites W2005984188 @default.
- W2038395323 cites W2007158544 @default.
- W2038395323 cites W2007547885 @default.
- W2038395323 cites W2008947883 @default.
- W2038395323 cites W2010796934 @default.
- W2038395323 cites W2013184309 @default.
- W2038395323 cites W2014775907 @default.
- W2038395323 cites W2018223807 @default.
- W2038395323 cites W2018270248 @default.
- W2038395323 cites W2018582204 @default.
- W2038395323 cites W2020114143 @default.
- W2038395323 cites W2020671330 @default.
- W2038395323 cites W2021468295 @default.
- W2038395323 cites W2022570079 @default.
- W2038395323 cites W2024347398 @default.
- W2038395323 cites W2024817951 @default.
- W2038395323 cites W2026760671 @default.
- W2038395323 cites W2027324522 @default.
- W2038395323 cites W2029517266 @default.
- W2038395323 cites W2031526576 @default.
- W2038395323 cites W2031993439 @default.
- W2038395323 cites W2033456044 @default.
- W2038395323 cites W2035729249 @default.
- W2038395323 cites W2035804328 @default.
- W2038395323 cites W2035995899 @default.
- W2038395323 cites W2039845507 @default.
- W2038395323 cites W2040091965 @default.
- W2038395323 cites W2042270713 @default.
- W2038395323 cites W2042394469 @default.
- W2038395323 cites W2044010024 @default.
- W2038395323 cites W2046464880 @default.
- W2038395323 cites W2046559925 @default.
- W2038395323 cites W2046623306 @default.
- W2038395323 cites W2049440252 @default.
- W2038395323 cites W2050792510 @default.
- W2038395323 cites W2051010978 @default.
- W2038395323 cites W2052297197 @default.
- W2038395323 cites W2052919896 @default.
- W2038395323 cites W2052975002 @default.
- W2038395323 cites W2056087694 @default.
- W2038395323 cites W2057810996 @default.
- W2038395323 cites W2059476430 @default.
- W2038395323 cites W2059576070 @default.
- W2038395323 cites W2061444197 @default.
- W2038395323 cites W2067580427 @default.
- W2038395323 cites W2068180882 @default.
- W2038395323 cites W2070120128 @default.
- W2038395323 cites W2070498479 @default.
- W2038395323 cites W2073234277 @default.
- W2038395323 cites W2074956054 @default.
- W2038395323 cites W2078401649 @default.
- W2038395323 cites W2078569105 @default.
- W2038395323 cites W2078762449 @default.
- W2038395323 cites W2080086264 @default.
- W2038395323 cites W2080240177 @default.
- W2038395323 cites W2080367130 @default.
- W2038395323 cites W2080430552 @default.