Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038399319> ?p ?o ?g. }
- W2038399319 endingPage "2229" @default.
- W2038399319 startingPage "2219" @default.
- W2038399319 abstract "Amphetamine-induced hydroxyl radical formation in the striatum of rats was investigated in this study. With the utilization of the microdialysis and HPLC-ECD, the striatal dopamine (DA) release and the formation of 2,3-dihydroxybenzoic acid (2,3-DHBA), derived from the reaction of hydroxyl radicals (·-OH) and salicylate in perfusion, were monitored and detected during desipramine and/or amphetamine (AMPH) administration. Our data revealed that after desipramine treatment AMPH injections not only amplified striatal DA release and 2,3-DHBA formation, but also intensified the stereotyped behaviors induced by AMPH. Furthermore, we discovered that α-methyl-para-tyrosine (α-MT) pretreatment prevented the onset of the above responses. In desipramine-treated rats, the tissue homogenization study demonstrated that a single dose of AMPH produced long-term depletion of striatal DA; this was not seen in saline-treated rats. Moreover, striatal DA depletion could be lessened by pretreatment with mannitol, a·.OH scavenger. These results indicate that AMPH-induced striatal.OH formation might be DA-related in desipramine-treated rats, and suggest that ·.OH formation might be correlated with AMPH-induced neurodegeneration." @default.
- W2038399319 created "2016-06-24" @default.
- W2038399319 creator A5008613472 @default.
- W2038399319 creator A5018990563 @default.
- W2038399319 creator A5043200991 @default.
- W2038399319 creator A5052731239 @default.
- W2038399319 date "1997-10-01" @default.
- W2038399319 modified "2023-10-11" @default.
- W2038399319 title "Amphetamine induces hydroxyl radical formation in the striatum of rats" @default.
- W2038399319 cites W120966838 @default.
- W2038399319 cites W1501428936 @default.
- W2038399319 cites W1566713165 @default.
- W2038399319 cites W1576599655 @default.
- W2038399319 cites W1594281994 @default.
- W2038399319 cites W1963964108 @default.
- W2038399319 cites W1965006448 @default.
- W2038399319 cites W1978348298 @default.
- W2038399319 cites W1981835221 @default.
- W2038399319 cites W1985285096 @default.
- W2038399319 cites W1988949532 @default.
- W2038399319 cites W1989118896 @default.
- W2038399319 cites W1989851808 @default.
- W2038399319 cites W1991865867 @default.
- W2038399319 cites W1999200892 @default.
- W2038399319 cites W2008524165 @default.
- W2038399319 cites W2010205595 @default.
- W2038399319 cites W2012237496 @default.
- W2038399319 cites W2016293448 @default.
- W2038399319 cites W2017577705 @default.
- W2038399319 cites W2018482346 @default.
- W2038399319 cites W2019109615 @default.
- W2038399319 cites W2021390693 @default.
- W2038399319 cites W2021479980 @default.
- W2038399319 cites W2024552547 @default.
- W2038399319 cites W2029797181 @default.
- W2038399319 cites W2032020105 @default.
- W2038399319 cites W2032950110 @default.
- W2038399319 cites W2035205866 @default.
- W2038399319 cites W2038967427 @default.
- W2038399319 cites W2053614981 @default.
- W2038399319 cites W2054721393 @default.
- W2038399319 cites W2066214697 @default.
- W2038399319 cites W2070390840 @default.
- W2038399319 cites W2083680902 @default.
- W2038399319 cites W2090811746 @default.
- W2038399319 cites W2103700558 @default.
- W2038399319 cites W2129902275 @default.
- W2038399319 cites W2328040924 @default.
- W2038399319 doi "https://doi.org/10.1016/s0024-3205(97)00924-7" @default.
- W2038399319 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9393941" @default.
- W2038399319 hasPublicationYear "1997" @default.
- W2038399319 type Work @default.
- W2038399319 sameAs 2038399319 @default.
- W2038399319 citedByCount "55" @default.
- W2038399319 countsByYear W20383993192012 @default.
- W2038399319 countsByYear W20383993192014 @default.
- W2038399319 countsByYear W20383993192015 @default.
- W2038399319 countsByYear W20383993192016 @default.
- W2038399319 countsByYear W20383993192017 @default.
- W2038399319 countsByYear W20383993192018 @default.
- W2038399319 countsByYear W20383993192022 @default.
- W2038399319 crossrefType "journal-article" @default.
- W2038399319 hasAuthorship W2038399319A5008613472 @default.
- W2038399319 hasAuthorship W2038399319A5018990563 @default.
- W2038399319 hasAuthorship W2038399319A5043200991 @default.
- W2038399319 hasAuthorship W2038399319A5052731239 @default.
- W2038399319 hasConcept C126322002 @default.
- W2038399319 hasConcept C139066938 @default.
- W2038399319 hasConcept C185592680 @default.
- W2038399319 hasConcept C2776778087 @default.
- W2038399319 hasConcept C2777193897 @default.
- W2038399319 hasConcept C2779177272 @default.
- W2038399319 hasConcept C2780062018 @default.
- W2038399319 hasConcept C2780250439 @default.
- W2038399319 hasConcept C2781161787 @default.
- W2038399319 hasConcept C28406088 @default.
- W2038399319 hasConcept C50156730 @default.
- W2038399319 hasConcept C513476851 @default.
- W2038399319 hasConcept C55493867 @default.
- W2038399319 hasConcept C71924100 @default.
- W2038399319 hasConcept C98274493 @default.
- W2038399319 hasConceptScore W2038399319C126322002 @default.
- W2038399319 hasConceptScore W2038399319C139066938 @default.
- W2038399319 hasConceptScore W2038399319C185592680 @default.
- W2038399319 hasConceptScore W2038399319C2776778087 @default.
- W2038399319 hasConceptScore W2038399319C2777193897 @default.
- W2038399319 hasConceptScore W2038399319C2779177272 @default.
- W2038399319 hasConceptScore W2038399319C2780062018 @default.
- W2038399319 hasConceptScore W2038399319C2780250439 @default.
- W2038399319 hasConceptScore W2038399319C2781161787 @default.
- W2038399319 hasConceptScore W2038399319C28406088 @default.
- W2038399319 hasConceptScore W2038399319C50156730 @default.
- W2038399319 hasConceptScore W2038399319C513476851 @default.
- W2038399319 hasConceptScore W2038399319C55493867 @default.
- W2038399319 hasConceptScore W2038399319C71924100 @default.
- W2038399319 hasConceptScore W2038399319C98274493 @default.
- W2038399319 hasIssue "22" @default.
- W2038399319 hasLocation W20383993191 @default.