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- W2038402783 abstract "Abstract The melanocortin 1 receptor ( MC 1R), a G protein‐coupled receptor preferentially expressed in melanocytes, mediates the pigmentary effects of α melanocyte‐stimulating hormone ( α MSH ). MC 1R is also expressed in other cutaneous cell types, particularly keratinocytes and dermal fibroblasts, suggesting non‐pigmentary actions of the α MSH / MC 1R system. Böhm and Stegemann now report a dramatic effect of mouse Mc1r functional status on susceptibility to skin fibrosis and collagen types I and III metabolism, in a study combining the powerful mouse model provided by the natural Mc1r e/e knockout and an established model of skin fibrosis. The study underscores the antifibrotic role for the skin α MSH / MC 1R system." @default.
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- W2038402783 date "2014-05-28" @default.
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- W2038402783 title "Melanocortin 1 receptor and skin pathophysiology: beyond colour, much more than meets the eye" @default.
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- W2038402783 doi "https://doi.org/10.1111/exd.12310" @default.
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