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- W2038405812 abstract "In an effort to optimize DNA immunization-elicited antibody production responses against Aβ1–42 (Aβ42) as a therapy for Alzheimer's disease (AD), comparisons were made between three distinct plasmid systems using gene gun delivery. Plasmids encoding Aβ42 monomer and a novel Aβ42 trimeric fusion protein were evaluated in conjunction with CMV or Gal4/UAS promoter elements. It was found that vaccination Aβ42 trimer under the Gal4/UAS promoter elicited high levels of anti-Aβ42 antibody production. Serum antibody levels from Gal4/UAS-Aβ42 trimer immunized mice were found to be 16.6 ± 5.5 μg/ml compared to 6.5 ± 2.5 μg/ml with Gal4/UAS-Aβ42 monomer or even less with CMV-Aβ42 trimer. As compared to monomeric Aβ42 or Aβ42 trimer expressed under the CMV promoter, injection of the Gal4/UAS-Aβ42 trimer induced high levels of Aβ42 antigen expression in tissue suggesting a mechanism for the increase in anti-Aβ42 antibody. Antibodies were found to be primarily IgG1 suggesting a predominant Th2 response (IgG1/IgG2a ratio of 9). Serum from Aβ42 trimer-vaccinated mice was also found to identify amyloid plaques in the brains of APP/PS1 transgenic mice. These results demonstrate the potential therapeutic use of Gal4/UAS DNA Aβ42 trimer immunization in preventing Alzheimer's disease." @default.
- W2038405812 created "2016-06-24" @default.
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- W2038405812 date "2010-07-01" @default.
- W2038405812 modified "2023-09-27" @default.
- W2038405812 title "Analysis of three plasmid systems for use in DNA Aβ42 immunization as therapy for Alzheimer's disease" @default.
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- W2038405812 doi "https://doi.org/10.1016/j.vaccine.2010.05.054" @default.
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