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- W2038410733 abstract "<h3>To the Editor.—</h3> We commend Goodman et al<sup>1</sup>for their rigorous study on the effectiveness of fluvoxamine in obsessive-compulsive disorder (OCD) and for the comprehensive and scholarly review on the possible mechanisms of action of 5-hydroxytryptamine (5-HT) reuptake blockers in OCD. We believe, however, that the issue of 5-HT autoreceptor desensitization deserves some clarification. Indeed, these authors stated correctly that long-term administration of 5-HT reuptake blockers leads to an enhanced 5-HT neurotransmission through 5-HT autoreceptor desensitization. However, they failed to specify that both the<i>somatodendritic</i>and<i>terminal</i>5-HT autoreceptors (Figure) are desensitized following long-term treatment with 5-HT reuptake blockers.<sup>2,3</sup>In contrast, long-term treatment with monoamine oxidase (MAO) inhibitors, while inducing desensitization of somatodendritic 5-HT autoreceptors,<sup>4</sup>does not modify the function of terminal 5-HT autoreceptors.<sup>3,5</sup> 5-HT Neuron Postsynaptic Neuron Somatodendritic 5-HT Autoreceptor Terminal 5-HT Autoreceptor Postsynaptic 5-HT Receptor Schematic representation of the localization of the different 5-HT" @default.
- W2038410733 created "2016-06-24" @default.
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- W2038410733 date "1991-05-01" @default.
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- W2038410733 title "Desensitization of Terminal 5-HT Autoreceptors by 5-HT Reuptake Blockers" @default.
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- W2038410733 doi "https://doi.org/10.1001/archpsyc.1991.01810290095019" @default.
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