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• W2038412514 abstract "Article AbstractObjective: To determine the efficacy of D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders.Data Sources and Study Selection: Using the search terms D-cycloserine AND anxiety disorders (MeSH), PubMed (1965-June 2011), PsycINFO, and Scopus were searched for randomized, double-blind, placebo-controlled trials of D-cycloserine augmentation of behavioral therapy for the treatment of anxiety disorders. Anxiety disorders were defined as any disorder categorized as such in DSM-IV-TR.Data Extraction: A random-effects model was used to calculate the standardized mean difference of change in anxiety rating scale scores with D-cycloserine augmentation compared to placebo, which was the primary outcome measure. Subgroup analysis and meta-regression were used to examine the effects of D-cycloserine dosage and timing (relative to exposure therapy), diagnostic indication, number of therapy sessions, and trial methodological quality on D-cycloserine efficacy.Results: Meta-analysis of 9 trials involving 273 subjects demonstrated a significant benefit from D-cycloserine augmentation (standardized mean difference = 0.46 , z = 2.89, P = .004). There was no evidence of publication bias, but a moderate, nonsignificant degree of heterogeneity between trials (I2 = 36%, Q = 12.6, df = 8, P = .12) was found. Secondary analyses yielded no significant findings.Conclusions: D-Cycloserine appears to be an effective augmentation agent that enhances the effects of behavioral therapy in the treatment of anxiety disorders. In contrast to a previous meta-analysis that examined D-cycloserine's effects in both animals and humans, we found no evidence of an effect of dose number, dose timing, or dosage of D-cycloserine on reported efficacy in the ranges studied.J Clin Psychiatry 2012;73(4):533-537© Copyright 2012 Physicians Postgraduate Press, Inc." @default.
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• W2038412514 date "2012-04-15" @default.
• W2038412514 modified "2023-09-23" @default.
• W2038412514 title "<scp>d</scp>-Cycloserine Augmentation of Behavioral Therapy for the Treatment of Anxiety Disorders" @default.
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• W2038412514 doi "https://doi.org/10.4088/jcp.11r07356" @default.
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