FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038418056> ?p ?o ?g. }

• W2038418056 endingPage "519" @default.
• W2038418056 startingPage "513" @default.
• W2038418056 abstract "Colorectal adenomatous and, probably, hyperplastic polyp development requires epithelial remodelling and stratification, with loss of E-cadherin expression implicated in adenoma formation. We have shown that P-cadherin, normally expressed in stratified epithelia and placenta, is aberrantly expressed in disturbed epithelial architecture associated with colitis.(i) To investigate the role of P-cadherin in colonic polyp formation. (ii) To ascertain whether expression of P-cadherin is independent of or correlated with expression of its associated proteins--E-cadherin, beta-catenin, and gamma-catenin. (iii) To determine if P-cadherin is functional regarding catenin binding in polyps.Expression and localisation of cadherins (E- and P-) and their associated catenins (beta- and gamma-) were determined in aberrant crypt foci (ACF), in polyps with hyperplastic morphology (hyperplastic polyps and serrated adenomas), and in adenomatous polyps by immunohistochemistry, western blotting, and mRNA in situ hybridisation. Assessment of cadherin-catenin binding was evaluated by co-immunoprecipitation. Adenomatous polyposis coli (APC) mutation was assessed in adenomatous polyps.P-cadherin was expressed from ACF through to hyperplastic and adenomatous polyps. Alterations in E-cadherin and catenin expression occurred later, with variant patterns in (i) ACF, (ii) hyperplastic polyps and serrated adenomas, and (iii) adenomatous polyps. P-cadherin present in adenomas was functional with regard to catenin binding, and its expression was independent of APC mutational status.P-cadherin is aberrantly expressed from the earliest morphologically identifiable stage of colonocyte transformation, prior to changes in E-cadherin, catenin, and APC expression/mutation. P-cadherin expression alone does not predict tissue morphology, and such expression is independent of that of associated cadherins and catenins." @default.
• W2038418056 created "2016-06-24" @default.
• W2038418056 creator A5002224261 @default.
• W2038418056 creator A5016328047 @default.
• W2038418056 creator A5034762894 @default.
• W2038418056 creator A5042681765 @default.
• W2038418056 creator A5049673440 @default.
• W2038418056 creator A5050261696 @default.
• W2038418056 creator A5055509208 @default.
• W2038418056 creator A5074888361 @default.
• W2038418056 creator A5085214846 @default.
• W2038418056 creator A5091186760 @default.
• W2038418056 date "2002-04-01" @default.
• W2038418056 modified "2023-10-09" @default.
• W2038418056 title "Aberrant P-cadherin expression is an early event in hyperplastic and dysplastic transformation in the colon" @default.
• W2038418056 cites W121819643 @default.
• W2038418056 cites W148077135 @default.
• W2038418056 cites W1507707983 @default.
• W2038418056 cites W1521591962 @default.
• W2038418056 cites W1554815317 @default.
• W2038418056 cites W1663072708 @default.
• W2038418056 cites W1784705092 @default.
• W2038418056 cites W1877472591 @default.
• W2038418056 cites W1969231537 @default.
• W2038418056 cites W1975895074 @default.
• W2038418056 cites W1990489545 @default.
• W2038418056 cites W1994478382 @default.
• W2038418056 cites W1996588062 @default.
• W2038418056 cites W2002404925 @default.
• W2038418056 cites W2011812152 @default.
• W2038418056 cites W2014515849 @default.
• W2038418056 cites W2016067272 @default.
• W2038418056 cites W2027586189 @default.
• W2038418056 cites W2036094375 @default.
• W2038418056 cites W2036864436 @default.
• W2038418056 cites W2051032088 @default.
• W2038418056 cites W2061975273 @default.
• W2038418056 cites W2074073812 @default.
• W2038418056 cites W2074453811 @default.
• W2038418056 cites W2074951823 @default.
• W2038418056 cites W2075460910 @default.
• W2038418056 cites W2081865235 @default.
• W2038418056 cites W2081893086 @default.
• W2038418056 cites W2097098623 @default.
• W2038418056 cites W2105015609 @default.
• W2038418056 cites W2107746069 @default.
• W2038418056 cites W2118184847 @default.
• W2038418056 cites W2127218675 @default.
• W2038418056 cites W2132475598 @default.
• W2038418056 cites W2143646667 @default.
• W2038418056 cites W2154722774 @default.
• W2038418056 cites W2171080110 @default.
• W2038418056 cites W2171854519 @default.
• W2038418056 cites W50786528 @default.
• W2038418056 doi "https://doi.org/10.1136/gut.50.4.513" @default.
• W2038418056 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1773182" @default.
• W2038418056 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11889072" @default.
• W2038418056 hasPublicationYear "2002" @default.
• W2038418056 type Work @default.
• W2038418056 sameAs 2038418056 @default.
• W2038418056 citedByCount "62" @default.
• W2038418056 countsByYear W20384180562012 @default.
• W2038418056 countsByYear W20384180562014 @default.
• W2038418056 countsByYear W20384180562015 @default.
• W2038418056 countsByYear W20384180562016 @default.
• W2038418056 countsByYear W20384180562017 @default.
• W2038418056 countsByYear W20384180562019 @default.
• W2038418056 countsByYear W20384180562020 @default.
• W2038418056 countsByYear W20384180562021 @default.
• W2038418056 countsByYear W20384180562022 @default.
• W2038418056 countsByYear W20384180562023 @default.
• W2038418056 crossrefType "journal-article" @default.
• W2038418056 hasAuthorship W2038418056A5002224261 @default.
• W2038418056 hasAuthorship W2038418056A5016328047 @default.
• W2038418056 hasAuthorship W2038418056A5034762894 @default.
• W2038418056 hasAuthorship W2038418056A5042681765 @default.
• W2038418056 hasAuthorship W2038418056A5049673440 @default.
• W2038418056 hasAuthorship W2038418056A5050261696 @default.
• W2038418056 hasAuthorship W2038418056A5055509208 @default.
• W2038418056 hasAuthorship W2038418056A5074888361 @default.
• W2038418056 hasAuthorship W2038418056A5085214846 @default.
• W2038418056 hasAuthorship W2038418056A5091186760 @default.
• W2038418056 hasBestOaLocation W20384180561 @default.
• W2038418056 hasConcept C104317684 @default.
• W2038418056 hasConcept C121608353 @default.
• W2038418056 hasConcept C137620995 @default.
• W2038418056 hasConcept C142724271 @default.
• W2038418056 hasConcept C1491633281 @default.
• W2038418056 hasConcept C149402561 @default.
• W2038418056 hasConcept C204232928 @default.
• W2038418056 hasConcept C2777428134 @default.
• W2038418056 hasConcept C2777562237 @default.
• W2038418056 hasConcept C2778237340 @default.
• W2038418056 hasConcept C2778435480 @default.
• W2038418056 hasConcept C2779324961 @default.
• W2038418056 hasConcept C2780814781 @default.
• W2038418056 hasConcept C2908781503 @default.
• W2038418056 hasConcept C30145163 @default.

• next