FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038424320> ?p ?o ?g. }

• W2038424320 endingPage "2576" @default.
• W2038424320 startingPage "2572" @default.
• W2038424320 abstract "Guanylhydrazones are cationic heteroaromatic drugs similar to the diamidines which are effective in the treatment of African trypanosomiasis and pneumocystosis. On the basis of their antitrypanosomal activity, different guanylhydrazones were selected for evaluation in a rat model of Pneumocystis carinii pneumonia. The most active compounds were the 2-(4'-formylphenyl)-1-methylimidazo-[1,2-a] pyridinium guanylhydrazones which, at a dose of 2 mg/kg/day, were about as effective as trimethoprim-sulfamethoxazole at a dose of 50 mg of trimethoprim per kg/day plus 250 mg of sulfamethoxazole per kg/day. The anti-P. carinii activity of these guanylhydrazone derivatives was found with parenteral but not with oral administration. The 1,3-arylene diketone bis(guanylhydrazones) were generally ineffective, although a triacetyl derivative showed some anti-P. carinii activity. Nitroimidazole guanylhydrazone derivatives were also ineffective. Attempts to improve the therapeutic efficacy of the different guanylhydrazones were limited by problems of toxicity. We conclude that some guanylhydrazone derivatives are potent anti-P. carinii drugs and that further studies should be pursued to develop safer compounds and investigate structure-activity relationships." @default.
• W2038424320 created "2016-06-24" @default.
• W2038424320 creator A5032729431 @default.
• W2038424320 creator A5041574411 @default.
• W2038424320 creator A5047827646 @default.
• W2038424320 creator A5067527782 @default.
• W2038424320 creator A5074740051 @default.
• W2038424320 creator A5076615191 @default.
• W2038424320 creator A5078061422 @default.
• W2038424320 creator A5087724216 @default.
• W2038424320 date "1994-11-01" @default.
• W2038424320 modified "2023-10-13" @default.
• W2038424320 title "Guanylhydrazones in therapy of Pneumocystis carinii pneumonia in immunosuppressed rats" @default.
• W2038424320 cites W1823219049 @default.
• W2038424320 cites W1965986754 @default.
• W2038424320 cites W1970055926 @default.
• W2038424320 cites W1972699689 @default.
• W2038424320 cites W1975222435 @default.
• W2038424320 cites W1975833163 @default.
• W2038424320 cites W1979526745 @default.
• W2038424320 cites W1996594757 @default.
• W2038424320 cites W1998698117 @default.
• W2038424320 cites W2003703135 @default.
• W2038424320 cites W2012116086 @default.
• W2038424320 cites W2017784952 @default.
• W2038424320 cites W2021031955 @default.
• W2038424320 cites W2024923808 @default.
• W2038424320 cites W2028537494 @default.
• W2038424320 cites W2029939319 @default.
• W2038424320 cites W2030658599 @default.
• W2038424320 cites W2036515598 @default.
• W2038424320 cites W2037827450 @default.
• W2038424320 cites W2066645019 @default.
• W2038424320 cites W2075648126 @default.
• W2038424320 cites W2148575374 @default.
• W2038424320 cites W2153575993 @default.
• W2038424320 cites W2157094125 @default.
• W2038424320 cites W2157337826 @default.
• W2038424320 cites W2952016738 @default.
• W2038424320 cites W2338529468 @default.
• W2038424320 doi "https://doi.org/10.1128/aac.38.11.2572" @default.
• W2038424320 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/188244" @default.
• W2038424320 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7872750" @default.
• W2038424320 hasPublicationYear "1994" @default.
• W2038424320 type Work @default.
• W2038424320 sameAs 2038424320 @default.
• W2038424320 citedByCount "13" @default.
• W2038424320 countsByYear W20384243202014 @default.
• W2038424320 countsByYear W20384243202016 @default.
• W2038424320 countsByYear W20384243202020 @default.
• W2038424320 countsByYear W20384243202023 @default.
• W2038424320 crossrefType "journal-article" @default.
• W2038424320 hasAuthorship W2038424320A5032729431 @default.
• W2038424320 hasAuthorship W2038424320A5041574411 @default.
• W2038424320 hasAuthorship W2038424320A5047827646 @default.
• W2038424320 hasAuthorship W2038424320A5067527782 @default.
• W2038424320 hasAuthorship W2038424320A5074740051 @default.
• W2038424320 hasAuthorship W2038424320A5076615191 @default.
• W2038424320 hasAuthorship W2038424320A5078061422 @default.
• W2038424320 hasAuthorship W2038424320A5087724216 @default.
• W2038424320 hasBestOaLocation W20384243202 @default.
• W2038424320 hasConcept C126322002 @default.
• W2038424320 hasConcept C2777530519 @default.
• W2038424320 hasConcept C2777559004 @default.
• W2038424320 hasConcept C2777914695 @default.
• W2038424320 hasConcept C2778994148 @default.
• W2038424320 hasConcept C2780728791 @default.
• W2038424320 hasConcept C29730261 @default.
• W2038424320 hasConcept C2993443204 @default.
• W2038424320 hasConcept C501593827 @default.
• W2038424320 hasConcept C71924100 @default.
• W2038424320 hasConcept C86803240 @default.
• W2038424320 hasConcept C89423630 @default.
• W2038424320 hasConcept C98274493 @default.
• W2038424320 hasConceptScore W2038424320C126322002 @default.
• W2038424320 hasConceptScore W2038424320C2777530519 @default.
• W2038424320 hasConceptScore W2038424320C2777559004 @default.
• W2038424320 hasConceptScore W2038424320C2777914695 @default.
• W2038424320 hasConceptScore W2038424320C2778994148 @default.
• W2038424320 hasConceptScore W2038424320C2780728791 @default.
• W2038424320 hasConceptScore W2038424320C29730261 @default.
• W2038424320 hasConceptScore W2038424320C2993443204 @default.
• W2038424320 hasConceptScore W2038424320C501593827 @default.
• W2038424320 hasConceptScore W2038424320C71924100 @default.
• W2038424320 hasConceptScore W2038424320C86803240 @default.
• W2038424320 hasConceptScore W2038424320C89423630 @default.
• W2038424320 hasConceptScore W2038424320C98274493 @default.
• W2038424320 hasIssue "11" @default.
• W2038424320 hasLocation W20384243201 @default.
• W2038424320 hasLocation W20384243202 @default.
• W2038424320 hasLocation W20384243203 @default.
• W2038424320 hasOpenAccess W2038424320 @default.
• W2038424320 hasPrimaryLocation W20384243201 @default.
• W2038424320 hasRelatedWork W2011525824 @default.
• W2038424320 hasRelatedWork W2028136003 @default.
• W2038424320 hasRelatedWork W2120209201 @default.
• W2038424320 hasRelatedWork W2126381453 @default.
• W2038424320 hasRelatedWork W2406102630 @default.

• next