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- W2038424651 abstract "Microsome-mediated metabolic activation of aflatoxin B1 (AFB1) and benzo[a]-pyrene (BP), as determined by the in vitro formation of DNA binding metabolites, was studied, using hepatic microsomes from untreated, phenobarbital (PB)-treated and 3-methylcholanthrene (MC)-treated male rats. Contrasting results were obtained for the two substrates: in the case of AFB1, microsomes from PB-treated rats were twice as active as microsomes from untreated and MC-treated rats, whereas, in the case of BP, microsomes from MC-treated rats were several fold more active than microsomes from untreated and PB-treated rats. These data strongly suggests enzyme multiplicity of microsomal mixed function oxygenase for the activation of carcinogens, especially AFB1 and BP whose reactive metabolites are believed to be epoxides." @default.
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- W2038424651 date "1974-11-01" @default.
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- W2038424651 title "Hepatic microsomal mixed function oxygenase: Enzyme multiplicity for the metabolism of carcinogens to DNA-binding metabolites" @default.
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- W2038424651 doi "https://doi.org/10.1016/0006-291x(74)91019-5" @default.
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