Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038429207> ?p ?o ?g. }
- W2038429207 endingPage "19967" @default.
- W2038429207 startingPage "19962" @default.
- W2038429207 abstract "The mechanisms by which ethanol damages the developing and adult central nervous system (CNS) remain unclear. Activity-dependent neuroprotective protein (ADNP) is a glial protein that protects the CNS against a wide array of insults and is critical for CNS development. NAPVSIPQ (NAP), a potent active fragment of ADNP, potentiated axon outgrowth in cerebellar granule neurons by activating the sequential tyrosine phosphorylation of Fyn kinase and the scaffold protein Crk-associated substrate (Cas). Pharmacological inhibition of Fyn kinase or expression of a Fyn kinase siRNA abolished NAP-mediated axon outgrowth. Concentrations of ethanol attained after social drinking blocked NAP-mediated axon outgrowth (IC(50) = 17 mM) by inhibiting NAP activation of Fyn kinase and Cas. These findings identify a mechanism for ADNP regulation of glial-neuronal interactions in developing cerebellum and a pathogenesis of ethanol neurotoxicity." @default.
- W2038429207 created "2016-06-24" @default.
- W2038429207 creator A5012020885 @default.
- W2038429207 creator A5051866095 @default.
- W2038429207 date "2008-12-16" @default.
- W2038429207 modified "2023-10-04" @default.
- W2038429207 title "Ethanol inhibits neuronal differentiation by disrupting activity-dependent neuroprotective protein signaling" @default.
- W2038429207 cites W139516685 @default.
- W2038429207 cites W1532742668 @default.
- W2038429207 cites W1539927687 @default.
- W2038429207 cites W1833413198 @default.
- W2038429207 cites W1968957195 @default.
- W2038429207 cites W1976243808 @default.
- W2038429207 cites W1978515376 @default.
- W2038429207 cites W1979302187 @default.
- W2038429207 cites W1984944464 @default.
- W2038429207 cites W1985630952 @default.
- W2038429207 cites W1990736154 @default.
- W2038429207 cites W1992444604 @default.
- W2038429207 cites W1994030229 @default.
- W2038429207 cites W2001381614 @default.
- W2038429207 cites W2011757937 @default.
- W2038429207 cites W2012593975 @default.
- W2038429207 cites W2019410709 @default.
- W2038429207 cites W2021819728 @default.
- W2038429207 cites W2029253143 @default.
- W2038429207 cites W2034249097 @default.
- W2038429207 cites W2039990215 @default.
- W2038429207 cites W2048117462 @default.
- W2038429207 cites W2076646611 @default.
- W2038429207 cites W2090895449 @default.
- W2038429207 cites W2091894475 @default.
- W2038429207 cites W2099802542 @default.
- W2038429207 cites W2114112734 @default.
- W2038429207 cites W2115136264 @default.
- W2038429207 cites W2146724329 @default.
- W2038429207 cites W2150041156 @default.
- W2038429207 cites W2155346059 @default.
- W2038429207 cites W2157140132 @default.
- W2038429207 cites W2164513340 @default.
- W2038429207 cites W2170262134 @default.
- W2038429207 doi "https://doi.org/10.1073/pnas.0807758105" @default.
- W2038429207 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2604983" @default.
- W2038429207 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19047645" @default.
- W2038429207 hasPublicationYear "2008" @default.
- W2038429207 type Work @default.
- W2038429207 sameAs 2038429207 @default.
- W2038429207 citedByCount "39" @default.
- W2038429207 countsByYear W20384292072012 @default.
- W2038429207 countsByYear W20384292072013 @default.
- W2038429207 countsByYear W20384292072014 @default.
- W2038429207 countsByYear W20384292072015 @default.
- W2038429207 countsByYear W20384292072016 @default.
- W2038429207 countsByYear W20384292072017 @default.
- W2038429207 countsByYear W20384292072018 @default.
- W2038429207 countsByYear W20384292072020 @default.
- W2038429207 countsByYear W20384292072021 @default.
- W2038429207 crossrefType "journal-article" @default.
- W2038429207 hasAuthorship W2038429207A5012020885 @default.
- W2038429207 hasAuthorship W2038429207A5051866095 @default.
- W2038429207 hasBestOaLocation W20384292071 @default.
- W2038429207 hasConcept C107513589 @default.
- W2038429207 hasConcept C108636557 @default.
- W2038429207 hasConcept C169760540 @default.
- W2038429207 hasConcept C178790620 @default.
- W2038429207 hasConcept C184235292 @default.
- W2038429207 hasConcept C185592680 @default.
- W2038429207 hasConcept C25498285 @default.
- W2038429207 hasConcept C2777553839 @default.
- W2038429207 hasConcept C2779491297 @default.
- W2038429207 hasConcept C2779530196 @default.
- W2038429207 hasConcept C2780880337 @default.
- W2038429207 hasConcept C29730261 @default.
- W2038429207 hasConcept C37686147 @default.
- W2038429207 hasConcept C55493867 @default.
- W2038429207 hasConcept C62478195 @default.
- W2038429207 hasConcept C86803240 @default.
- W2038429207 hasConcept C95444343 @default.
- W2038429207 hasConcept C97029542 @default.
- W2038429207 hasConceptScore W2038429207C107513589 @default.
- W2038429207 hasConceptScore W2038429207C108636557 @default.
- W2038429207 hasConceptScore W2038429207C169760540 @default.
- W2038429207 hasConceptScore W2038429207C178790620 @default.
- W2038429207 hasConceptScore W2038429207C184235292 @default.
- W2038429207 hasConceptScore W2038429207C185592680 @default.
- W2038429207 hasConceptScore W2038429207C25498285 @default.
- W2038429207 hasConceptScore W2038429207C2777553839 @default.
- W2038429207 hasConceptScore W2038429207C2779491297 @default.
- W2038429207 hasConceptScore W2038429207C2779530196 @default.
- W2038429207 hasConceptScore W2038429207C2780880337 @default.
- W2038429207 hasConceptScore W2038429207C29730261 @default.
- W2038429207 hasConceptScore W2038429207C37686147 @default.
- W2038429207 hasConceptScore W2038429207C55493867 @default.
- W2038429207 hasConceptScore W2038429207C62478195 @default.
- W2038429207 hasConceptScore W2038429207C86803240 @default.
- W2038429207 hasConceptScore W2038429207C95444343 @default.
- W2038429207 hasConceptScore W2038429207C97029542 @default.
- W2038429207 hasIssue "50" @default.