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- W2038433182 abstract "The objective of the present study was to assess whether the anticonvulsant activity of melatonin displays diurnal variability in hamsters. Convulsions were induced by administering 3-mercaptopropionic acid (3-MP). There was a significant diurnal variation in 3-MP-induced convulsions, hamsters being more prone to exhibit seizures during the night than during the day. Melatonin (50 mg/kg i.p.) had a maximal anticonvulsive effect in the early evening (20:00 h). The administration at 20:00 h of the central-type benzodiazepine antagonist, Ro 15-1788, although unable by itself to modify seizure threshold, blunted the anticonvulsant response to melatonin. The results indicate that the time-dependent anticonvulsant activity of melatonin is sensitive to central-type benzodiazepine antagonism." @default.
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- W2038433182 date "1992-01-01" @default.
- W2038433182 modified "2023-10-14" @default.
- W2038433182 title "Time-dependent anticonvulsant activity of melatonin in hamsters" @default.
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- W2038433182 doi "https://doi.org/10.1016/0014-2999(92)90412-w" @default.
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