FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038435203> ?p ?o ?g. }

• W2038435203 endingPage "140" @default.
• W2038435203 startingPage "136" @default.
• W2038435203 abstract "We describe a patient with mild haemophilia A (original value of factor VIII activity 0.30 U/ml) who developed an inhibitor (36.1 Bethesda U/ml) which cross-reacted with his endogenous factor VIII. This caused a decline in basal factor VIII level (< 0.01 U/ml) and severe haemorrhagic events. Treatment to induce immune tolerance was started with factor VIII/von Willebrand factor (VWF) concentrates, but inhibitor levels increased progressively and the patient suffered serious bleeding. Cyclophosphamide was administered and, after 8 months treatment, factor VIII levels increased to 0.20 U/ml and the inhibitor could no longer be detected. Screening of his factor VIII gene revealed a missense mutation in exon 13 that predicts substitution of Asn618-->Ser in the A2 domain of factor VIII. Immunoprecipitation analysis showed that the antibodies present in the patient's plasma reacted with metabolically labelled A2 domain and, to a lesser extent, with factor VIII light chain. Inhibitory antibodies were completely neutralized by recombinant A2 domain, whereas no neutralization was observed after the addition of factor VIII light chain (A3-C1-C2) and C2 domain. More detailed analysis showed that the majority of inhibitory antibodies were directed against residues Arg484-Ile508, a previously identified binding site for factor VIII inhibitors. Our findings suggest that immune tolerance therapy and cyclophosphamide were successful in eradicating inhibitory antibodies against a common epitope on factor VIII." @default.
• W2038435203 created "2016-06-24" @default.
• W2038435203 creator A5043388264 @default.
• W2038435203 creator A5049251029 @default.
• W2038435203 creator A5058395925 @default.
• W2038435203 creator A5066886041 @default.
• W2038435203 creator A5072522782 @default.
• W2038435203 creator A5082206845 @default.
• W2038435203 creator A5090611983 @default.
• W2038435203 date "2002-03-25" @default.
• W2038435203 modified "2023-10-17" @default.
• W2038435203 title "Factor VIII inhibitor in a patient with mild haemophilia A and an Asn⁶¹⁸ →Ser mutation responsive to immune tolerance induction and cyclophosphamide" @default.
• W2038435203 cites W1528709070 @default.
• W2038435203 cites W2026502021 @default.
• W2038435203 cites W2033266807 @default.
• W2038435203 cites W2053128936 @default.
• W2038435203 cites W2056634959 @default.
• W2038435203 cites W2075248695 @default.
• W2038435203 cites W2082897488 @default.
• W2038435203 cites W2083645573 @default.
• W2038435203 cites W2112592916 @default.
• W2038435203 cites W2148582603 @default.
• W2038435203 cites W2149564822 @default.
• W2038435203 cites W2158227826 @default.
• W2038435203 cites W2169465140 @default.
• W2038435203 cites W2270443168 @default.
• W2038435203 cites W2337290468 @default.
• W2038435203 cites W2411876225 @default.
• W2038435203 cites W2427589464 @default.
• W2038435203 cites W4249487565 @default.
• W2038435203 cites W4299800650 @default.
• W2038435203 cites W97786411 @default.
• W2038435203 cites W98859 @default.
• W2038435203 doi "https://doi.org/10.1046/j.1365-2141.2002.03383.x" @default.
• W2038435203 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11918545" @default.
• W2038435203 hasPublicationYear "2002" @default.
• W2038435203 type Work @default.
• W2038435203 sameAs 2038435203 @default.
• W2038435203 citedByCount "25" @default.
• W2038435203 countsByYear W20384352032012 @default.
• W2038435203 countsByYear W20384352032013 @default.
• W2038435203 countsByYear W20384352032014 @default.
• W2038435203 countsByYear W20384352032016 @default.
• W2038435203 countsByYear W20384352032018 @default.
• W2038435203 countsByYear W20384352032020 @default.
• W2038435203 countsByYear W20384352032022 @default.
• W2038435203 crossrefType "journal-article" @default.
• W2038435203 hasAuthorship W2038435203A5043388264 @default.
• W2038435203 hasAuthorship W2038435203A5049251029 @default.
• W2038435203 hasAuthorship W2038435203A5058395925 @default.
• W2038435203 hasAuthorship W2038435203A5066886041 @default.
• W2038435203 hasAuthorship W2038435203A5072522782 @default.
• W2038435203 hasAuthorship W2038435203A5082206845 @default.
• W2038435203 hasAuthorship W2038435203A5090611983 @default.
• W2038435203 hasConcept C126322002 @default.
• W2038435203 hasConcept C141071460 @default.
• W2038435203 hasConcept C153911025 @default.
• W2038435203 hasConcept C159654299 @default.
• W2038435203 hasConcept C195616568 @default.
• W2038435203 hasConcept C203014093 @default.
• W2038435203 hasConcept C2776694085 @default.
• W2038435203 hasConcept C2776755627 @default.
• W2038435203 hasConcept C2777081929 @default.
• W2038435203 hasConcept C2777232031 @default.
• W2038435203 hasConcept C2778385053 @default.
• W2038435203 hasConcept C2779394231 @default.
• W2038435203 hasConcept C2781221834 @default.
• W2038435203 hasConcept C71924100 @default.
• W2038435203 hasConcept C86803240 @default.
• W2038435203 hasConcept C8891405 @default.
• W2038435203 hasConcept C89560881 @default.
• W2038435203 hasConceptScore W2038435203C126322002 @default.
• W2038435203 hasConceptScore W2038435203C141071460 @default.
• W2038435203 hasConceptScore W2038435203C153911025 @default.
• W2038435203 hasConceptScore W2038435203C159654299 @default.
• W2038435203 hasConceptScore W2038435203C195616568 @default.
• W2038435203 hasConceptScore W2038435203C203014093 @default.
• W2038435203 hasConceptScore W2038435203C2776694085 @default.
• W2038435203 hasConceptScore W2038435203C2776755627 @default.
• W2038435203 hasConceptScore W2038435203C2777081929 @default.
• W2038435203 hasConceptScore W2038435203C2777232031 @default.
• W2038435203 hasConceptScore W2038435203C2778385053 @default.
• W2038435203 hasConceptScore W2038435203C2779394231 @default.
• W2038435203 hasConceptScore W2038435203C2781221834 @default.
• W2038435203 hasConceptScore W2038435203C71924100 @default.
• W2038435203 hasConceptScore W2038435203C86803240 @default.
• W2038435203 hasConceptScore W2038435203C8891405 @default.
• W2038435203 hasConceptScore W2038435203C89560881 @default.
• W2038435203 hasIssue "1" @default.
• W2038435203 hasLocation W20384352031 @default.
• W2038435203 hasLocation W20384352032 @default.
• W2038435203 hasOpenAccess W2038435203 @default.
• W2038435203 hasPrimaryLocation W20384352031 @default.
• W2038435203 hasRelatedWork W2005719195 @default.
• W2038435203 hasRelatedWork W2031327112 @default.
• W2038435203 hasRelatedWork W2067082011 @default.
• W2038435203 hasRelatedWork W2078332762 @default.
• W2038435203 hasRelatedWork W2101928171 @default.

• next