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- W2038444767 abstract "Abstract Rheumatoid arthritis (RA) is a chronic inflammatory disease regulated by differential T cell activity. A relative predominance of T-helper type 1 cytokine secretion patterns (T1) have been observed in the joint tissue. In vitro it had been shown that induction of T-helper type 2 cytokine secretion patterns (T2) reduced the expected joint damage. Four clinical studies are discussed that demonstrated that induction of T2 cell activity can ameliorate disease activity in patients with active RA. Beneficial effects were observed in hay fever patients, in patients with high IgE due to previous helminthic infections, in patients treated with dexamethasone and in pregnant RA patients. All studies supported the idea that disease activity of RA, regulated by T1 cell activity, can be suppressed by the induction of peripheral T2 cell activity. This may have implications for future treatment strategies in RA." @default.
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- W2038444767 date "2001-01-01" @default.
- W2038444767 modified "2023-09-27" @default.
- W2038444767 title "T1/T2 cell balance in rheumatoid arthritis" @default.
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- W2038444767 doi "https://doi.org/10.1016/s1529-1049(01)00025-3" @default.
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