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• W2038447903 endingPage "374" @default.
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• W2038447903 abstract "Abstract: : Cyclic peptide mixtures represent a promising approach for drug lead discovery. Diversity can be expanded via changes in ring size, amide bond replacements, d- and l-natural and unnatural amino acids, and by the incorporation of β-turn mimics and related conformational constraints. We expand the scope of our side-chain attachment/resin-bound cyclization strategy first developed using aspartic acid, asparagine, and related acid-based attachments. In this report, we describe the preparation and use of Boc-Lys-OFm, Boc-Orn-OFm, and Boc-Dab-OFm. The synthetic strategies were verified by the independent synthesis of two small RGD-based cyclic mixtures, cyclo(Pro-Xxx-Lys-Arg-Gly-Asp). where Xxx = Ala, Ser, Leu, Tyr, using Boc-Asp-OFm, and then Boc-Lys-OFm for the initial resin-bound side-chain linkage. A new orthogonal synthetic approach to cyclic peptides, based on the use of the para-nitrobenzyl (ONB) ester for a-carboxyl protection (selectively cleaved via SnCl2 reduction), was developed. It led to the successful synthesis of individual cyclic pentapeptides using serine (Boc-Ser-ONB), and tyrosine (Fmoc-Tyr-ONB) as the side chain-linked residues." @default.
• W2038447903 created "2016-06-24" @default.
• W2038447903 creator A5019258325 @default.
• W2038447903 creator A5080773870 @default.
• W2038447903 date "2009-01-12" @default.
• W2038447903 modified "2023-09-26" @default.
• W2038447903 title "Preparation of head-to-tail cyclic peptides via side-chain attachment: Implications for library synthesis" @default.
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• W2038447903 doi "https://doi.org/10.1111/j.1399-3011.1998.tb00660.x" @default.
• W2038447903 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9894841" @default.
• W2038447903 hasPublicationYear "2009" @default.
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