Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038454864> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2038454864 endingPage "275" @default.
- W2038454864 startingPage "265" @default.
- W2038454864 abstract "We examined the efficacy of using monoclonal antibodies to target antigen (avidin) to different surface molecules expressed on antigen presenting cells (APC). In particular, we targeted CD40 to test whether the adjuvant properties of CD40 signaling combined with targeted antigen would result in enhanced serologic responses. We targeted avidin to class II as a positive control and to CD11c as a negative control. These surface proteins represent an ensemble of surface molecules that signal upon ligation and that are expressed on professional APC, in particular dendritic cells (DC). We observed that targeting class II molecules on APC was superior to targeting CD40, or CD11c. However, CD40 and CD11c could function as targets for antigen bound monoclonal antibodies under certain conditions. Interestingly, inclusion of anti-CD40 mAb with the targeting anti-class II-targeted antigens negatively affects humoral response, suggesting that CD40 signaling under certain conditions may suppress processing and/or presentation of targeted antigen." @default.
- W2038454864 created "2016-06-24" @default.
- W2038454864 creator A5037217342 @default.
- W2038454864 creator A5047154491 @default.
- W2038454864 creator A5091338129 @default.
- W2038454864 date "2001-02-01" @default.
- W2038454864 modified "2023-10-06" @default.
- W2038454864 title "Class II-targeted antigen is superior to CD40-targeted antigen at stimulating humoral responses in vivo" @default.
- W2038454864 cites W1483922594 @default.
- W2038454864 cites W1522802573 @default.
- W2038454864 cites W1532427044 @default.
- W2038454864 cites W1562280149 @default.
- W2038454864 cites W1967230521 @default.
- W2038454864 cites W1983318869 @default.
- W2038454864 cites W2005259344 @default.
- W2038454864 cites W2008386552 @default.
- W2038454864 cites W2020255902 @default.
- W2038454864 cites W2027178598 @default.
- W2038454864 cites W2046410511 @default.
- W2038454864 cites W2055547051 @default.
- W2038454864 cites W2068320441 @default.
- W2038454864 cites W2072930832 @default.
- W2038454864 cites W2101492664 @default.
- W2038454864 cites W2127404676 @default.
- W2038454864 cites W2140944306 @default.
- W2038454864 cites W2152467957 @default.
- W2038454864 cites W2158244716 @default.
- W2038454864 cites W2168644212 @default.
- W2038454864 cites W4313348085 @default.
- W2038454864 cites W850616708 @default.
- W2038454864 doi "https://doi.org/10.1016/s1567-5769(00)00032-1" @default.
- W2038454864 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11360928" @default.
- W2038454864 hasPublicationYear "2001" @default.
- W2038454864 type Work @default.
- W2038454864 sameAs 2038454864 @default.
- W2038454864 citedByCount "10" @default.
- W2038454864 countsByYear W20384548642014 @default.
- W2038454864 countsByYear W20384548642020 @default.
- W2038454864 countsByYear W20384548642022 @default.
- W2038454864 countsByYear W20384548642023 @default.
- W2038454864 crossrefType "journal-article" @default.
- W2038454864 hasAuthorship W2038454864A5037217342 @default.
- W2038454864 hasAuthorship W2038454864A5047154491 @default.
- W2038454864 hasAuthorship W2038454864A5091338129 @default.
- W2038454864 hasConcept C147483822 @default.
- W2038454864 hasConcept C153911025 @default.
- W2038454864 hasConcept C154317977 @default.
- W2038454864 hasConcept C159654299 @default.
- W2038454864 hasConcept C202751555 @default.
- W2038454864 hasConcept C203014093 @default.
- W2038454864 hasConcept C2776090121 @default.
- W2038454864 hasConcept C39347974 @default.
- W2038454864 hasConcept C542903549 @default.
- W2038454864 hasConcept C55493867 @default.
- W2038454864 hasConcept C67662055 @default.
- W2038454864 hasConcept C83464605 @default.
- W2038454864 hasConcept C86803240 @default.
- W2038454864 hasConcept C8891405 @default.
- W2038454864 hasConcept C95444343 @default.
- W2038454864 hasConceptScore W2038454864C147483822 @default.
- W2038454864 hasConceptScore W2038454864C153911025 @default.
- W2038454864 hasConceptScore W2038454864C154317977 @default.
- W2038454864 hasConceptScore W2038454864C159654299 @default.
- W2038454864 hasConceptScore W2038454864C202751555 @default.
- W2038454864 hasConceptScore W2038454864C203014093 @default.
- W2038454864 hasConceptScore W2038454864C2776090121 @default.
- W2038454864 hasConceptScore W2038454864C39347974 @default.
- W2038454864 hasConceptScore W2038454864C542903549 @default.
- W2038454864 hasConceptScore W2038454864C55493867 @default.
- W2038454864 hasConceptScore W2038454864C67662055 @default.
- W2038454864 hasConceptScore W2038454864C83464605 @default.
- W2038454864 hasConceptScore W2038454864C86803240 @default.
- W2038454864 hasConceptScore W2038454864C8891405 @default.
- W2038454864 hasConceptScore W2038454864C95444343 @default.
- W2038454864 hasIssue "2" @default.
- W2038454864 hasLocation W20384548641 @default.
- W2038454864 hasLocation W20384548642 @default.
- W2038454864 hasOpenAccess W2038454864 @default.
- W2038454864 hasPrimaryLocation W20384548641 @default.
- W2038454864 hasRelatedWork W1603218207 @default.
- W2038454864 hasRelatedWork W202909702 @default.
- W2038454864 hasRelatedWork W2064089409 @default.
- W2038454864 hasRelatedWork W2077565043 @default.
- W2038454864 hasRelatedWork W2094482300 @default.
- W2038454864 hasRelatedWork W2368460920 @default.
- W2038454864 hasRelatedWork W2406510374 @default.
- W2038454864 hasRelatedWork W2415628465 @default.
- W2038454864 hasRelatedWork W39915895 @default.
- W2038454864 hasRelatedWork W4386790027 @default.
- W2038454864 hasVolume "1" @default.
- W2038454864 isParatext "false" @default.
- W2038454864 isRetracted "false" @default.
- W2038454864 magId "2038454864" @default.
- W2038454864 workType "article" @default.