FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038459645> ?p ?o ?g. }

• W2038459645 endingPage "583" @default.
• W2038459645 startingPage "575" @default.
• W2038459645 abstract "Objective To characterize biochemical changes in skeletal muscle in critically ill patients. Design Survey of critically ill patients. Setting Intensive care unit (ICU) at a university hospital. Patients Critically ill patients (n equals 20) subjected to trauma, surgical complications, and/or bacteremia who were treated in the ICU and showed no risk of bleeding complications were included. Reference groups of metabolically healthy volunteers and patients served as the control/reference groups. Interventions Percutaneous muscle biopsy was obtained from both patients and healthy volunteers. Measurements and Main Results Total free amino acids in skeletal muscle decreased 59% (p less than .001) and skeletal muscle glutamine concentration decreased 72% (p less than .001) in the critically ill patients. Basic amino acids decreased 49% (p less than .001). Branch-chain amino acids increased 39% (p less than .01), and aromatic amino acids increased 88% (p less than .001) in the patients. Adenosine triphosphate (ATP) was reduced by 12% (p less than .01). Total creatine concentration increased by 26% (p less than .001) due to an 80% increase in free creatine (p less than .001). The phosphorylated creatine fraction of total creatine decreased 22% (p less than .001) in the patients. Alkali-soluble protein/DNA decreased 24% (p less than .01) and fat free solid/DNA decreased 21% (p less than .01) in patients sampled on or after ICU day 5 compared with the reference group. Muscle water increased 10% due to a doubling of the extracellular water fraction. Conclusions Although critically ill patients are a very heterogeneous group from a clinical point of view, there is a remarkable homogeneity in many of the biochemical parameters regardless of the severity of illness and the length of the ICU admission. The three most consistent differences were the skeletal muscle low glutamine concentration, the decrease in protein content, and the increase in extracellular water in the patients. (Crit Care Med 1996; 24:575-583)" @default.
• W2038459645 created "2016-06-24" @default.
• W2038459645 creator A5005646726 @default.
• W2038459645 creator A5014627032 @default.
• W2038459645 creator A5023771529 @default.
• W2038459645 creator A5058989984 @default.
• W2038459645 creator A5074556836 @default.
• W2038459645 date "1996-04-01" @default.
• W2038459645 modified "2023-10-12" @default.
• W2038459645 title "A descriptive study of skeletal muscle metabolism in critically ill patients" @default.
• W2038459645 cites W133295433 @default.
• W2038459645 cites W1775749144 @default.
• W2038459645 cites W1983033947 @default.
• W2038459645 cites W1983549873 @default.
• W2038459645 cites W1984973279 @default.
• W2038459645 cites W1986262109 @default.
• W2038459645 cites W1986841467 @default.
• W2038459645 cites W2009127385 @default.
• W2038459645 cites W2011493774 @default.
• W2038459645 cites W2041686888 @default.
• W2038459645 cites W2052531933 @default.
• W2038459645 cites W2052986160 @default.
• W2038459645 cites W2057100497 @default.
• W2038459645 cites W2074812182 @default.
• W2038459645 cites W2079736335 @default.
• W2038459645 cites W2089148038 @default.
• W2038459645 cites W2102237454 @default.
• W2038459645 cites W2119282315 @default.
• W2038459645 cites W2174704610 @default.
• W2038459645 cites W2175344015 @default.
• W2038459645 cites W2325577150 @default.
• W2038459645 cites W2337817502 @default.
• W2038459645 cites W2409338682 @default.
• W2038459645 cites W2412496262 @default.
• W2038459645 cites W2417436784 @default.
• W2038459645 cites W4293242440 @default.
• W2038459645 doi "https://doi.org/10.1097/00003246-199604000-00005" @default.
• W2038459645 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8612406" @default.
• W2038459645 hasPublicationYear "1996" @default.
• W2038459645 type Work @default.
• W2038459645 sameAs 2038459645 @default.
• W2038459645 citedByCount "150" @default.
• W2038459645 countsByYear W20384596452012 @default.
• W2038459645 countsByYear W20384596452013 @default.
• W2038459645 countsByYear W20384596452014 @default.
• W2038459645 countsByYear W20384596452015 @default.
• W2038459645 countsByYear W20384596452016 @default.
• W2038459645 countsByYear W20384596452017 @default.
• W2038459645 countsByYear W20384596452018 @default.
• W2038459645 countsByYear W20384596452020 @default.
• W2038459645 countsByYear W20384596452021 @default.
• W2038459645 crossrefType "journal-article" @default.
• W2038459645 hasAuthorship W2038459645A5005646726 @default.
• W2038459645 hasAuthorship W2038459645A5014627032 @default.
• W2038459645 hasAuthorship W2038459645A5023771529 @default.
• W2038459645 hasAuthorship W2038459645A5058989984 @default.
• W2038459645 hasAuthorship W2038459645A5074556836 @default.
• W2038459645 hasConcept C126322002 @default.
• W2038459645 hasConcept C185592680 @default.
• W2038459645 hasConcept C2776376669 @default.
• W2038459645 hasConcept C2779349466 @default.
• W2038459645 hasConcept C2779896295 @default.
• W2038459645 hasConcept C2779959927 @default.
• W2038459645 hasConcept C2991859549 @default.
• W2038459645 hasConcept C515207424 @default.
• W2038459645 hasConcept C55493867 @default.
• W2038459645 hasConcept C71924100 @default.
• W2038459645 hasConceptScore W2038459645C126322002 @default.
• W2038459645 hasConceptScore W2038459645C185592680 @default.
• W2038459645 hasConceptScore W2038459645C2776376669 @default.
• W2038459645 hasConceptScore W2038459645C2779349466 @default.
• W2038459645 hasConceptScore W2038459645C2779896295 @default.
• W2038459645 hasConceptScore W2038459645C2779959927 @default.
• W2038459645 hasConceptScore W2038459645C2991859549 @default.
• W2038459645 hasConceptScore W2038459645C515207424 @default.
• W2038459645 hasConceptScore W2038459645C55493867 @default.
• W2038459645 hasConceptScore W2038459645C71924100 @default.
• W2038459645 hasIssue "4" @default.
• W2038459645 hasLocation W20384596451 @default.
• W2038459645 hasLocation W20384596452 @default.
• W2038459645 hasOpenAccess W2038459645 @default.
• W2038459645 hasPrimaryLocation W20384596451 @default.
• W2038459645 hasRelatedWork W1866222897 @default.
• W2038459645 hasRelatedWork W2016733795 @default.
• W2038459645 hasRelatedWork W2029624447 @default.
• W2038459645 hasRelatedWork W2081780014 @default.
• W2038459645 hasRelatedWork W2094643509 @default.
• W2038459645 hasRelatedWork W2111784969 @default.
• W2038459645 hasRelatedWork W2119738915 @default.
• W2038459645 hasRelatedWork W2331740731 @default.
• W2038459645 hasRelatedWork W2561547506 @default.
• W2038459645 hasRelatedWork W3008089983 @default.
• W2038459645 hasVolume "24" @default.
• W2038459645 isParatext "false" @default.
• W2038459645 isRetracted "false" @default.
• W2038459645 magId "2038459645" @default.
• W2038459645 workType "article" @default.