FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038461954> ?p ?o ?g. }

• W2038461954 endingPage "214" @default.
• W2038461954 startingPage "203" @default.
• W2038461954 abstract "Galectin 3 is a beta-galactoside binding protein which localizes to the cytoplasm of proliferative, mature, and hypertrophic chondrocytes in the growth plate cartilage of developing long bones. To elucidate the function of galectin 3 during bone development, we examined the epiphyseal femurs and tibias of fetal mice carrying a null mutation for the galectin 3 gene. Detailed histological and ultrastructural studies identified abnormalities in the cells of the proliferative, mature, and hypertrophic zones and in the extracellular matrix of the hypertrophic zone, as well as a reduction in the total number of hypertrophic chondrocytes. The expression patterns of several chondrocyte and bone cell markers were analyzed and revealed a subtle modification of Ihh expression in the galectin 3 mutant growth plate. A striking difference was observed at the chondrovascular junction where many empty lacunae are present. In addition, large numbers of condensed chondrocytes exhibiting characteristic signs of cell death were found in the late hypertrophic zone, indicating that the rate of chondrocyte death is increased in the mutants. These results suggest a role for galectin 3 as a regulator of chondrocyte survival. In addition, this unique phenotype shows that the elimination of chondrocytes and vascular invasion can be uncoupled and indicates that galectin 3 may play a role in the coordination between chondrocyte death and metaphyseal vascularization." @default.
• W2038461954 created "2016-06-24" @default.
• W2038461954 creator A5003314487 @default.
• W2038461954 creator A5004877142 @default.
• W2038461954 creator A5029176428 @default.
• W2038461954 creator A5091340457 @default.
• W2038461954 date "2001-01-01" @default.
• W2038461954 modified "2023-09-30" @default.
• W2038461954 title "Uncoupling of Chondrocyte Death and Vascular Invasion in Mouse Galectin 3 Null Mutant Bones" @default.
• W2038461954 cites W1576409652 @default.
• W2038461954 cites W1583699618 @default.
• W2038461954 cites W1638424324 @default.
• W2038461954 cites W1964519636 @default.
• W2038461954 cites W1970680780 @default.
• W2038461954 cites W1972819616 @default.
• W2038461954 cites W1974634741 @default.
• W2038461954 cites W1979901510 @default.
• W2038461954 cites W1980434442 @default.
• W2038461954 cites W1991424506 @default.
• W2038461954 cites W1991686744 @default.
• W2038461954 cites W1995499476 @default.
• W2038461954 cites W1995909770 @default.
• W2038461954 cites W2008563659 @default.
• W2038461954 cites W2009090465 @default.
• W2038461954 cites W2012337697 @default.
• W2038461954 cites W2016327551 @default.
• W2038461954 cites W2016411107 @default.
• W2038461954 cites W2020548763 @default.
• W2038461954 cites W2060490044 @default.
• W2038461954 cites W2065151410 @default.
• W2038461954 cites W2068851063 @default.
• W2038461954 cites W2075528851 @default.
• W2038461954 cites W2099437115 @default.
• W2038461954 cites W2099931271 @default.
• W2038461954 cites W2102911949 @default.
• W2038461954 cites W2110341920 @default.
• W2038461954 cites W2144589204 @default.
• W2038461954 cites W2157172418 @default.
• W2038461954 cites W2161508058 @default.
• W2038461954 cites W2168876853 @default.
• W2038461954 cites W2170335058 @default.
• W2038461954 cites W2244595585 @default.
• W2038461954 doi "https://doi.org/10.1006/dbio.2000.9933" @default.
• W2038461954 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11133164" @default.
• W2038461954 hasPublicationYear "2001" @default.
• W2038461954 type Work @default.
• W2038461954 sameAs 2038461954 @default.
• W2038461954 citedByCount "95" @default.
• W2038461954 countsByYear W20384619542012 @default.
• W2038461954 countsByYear W20384619542013 @default.
• W2038461954 countsByYear W20384619542014 @default.
• W2038461954 countsByYear W20384619542015 @default.
• W2038461954 countsByYear W20384619542016 @default.
• W2038461954 countsByYear W20384619542017 @default.
• W2038461954 countsByYear W20384619542018 @default.
• W2038461954 countsByYear W20384619542019 @default.
• W2038461954 countsByYear W20384619542020 @default.
• W2038461954 countsByYear W20384619542021 @default.
• W2038461954 countsByYear W20384619542023 @default.
• W2038461954 crossrefType "journal-article" @default.
• W2038461954 hasAuthorship W2038461954A5003314487 @default.
• W2038461954 hasAuthorship W2038461954A5004877142 @default.
• W2038461954 hasAuthorship W2038461954A5029176428 @default.
• W2038461954 hasAuthorship W2038461954A5091340457 @default.
• W2038461954 hasBestOaLocation W20384619541 @default.
• W2038461954 hasConcept C104317684 @default.
• W2038461954 hasConcept C105702510 @default.
• W2038461954 hasConcept C143065580 @default.
• W2038461954 hasConcept C150194340 @default.
• W2038461954 hasConcept C189165786 @default.
• W2038461954 hasConcept C190283241 @default.
• W2038461954 hasConcept C203014093 @default.
• W2038461954 hasConcept C2776336362 @default.
• W2038461954 hasConcept C2778486617 @default.
• W2038461954 hasConcept C2780550940 @default.
• W2038461954 hasConcept C2781403057 @default.
• W2038461954 hasConcept C31573885 @default.
• W2038461954 hasConcept C54355233 @default.
• W2038461954 hasConcept C86803240 @default.
• W2038461954 hasConcept C95444343 @default.
• W2038461954 hasConceptScore W2038461954C104317684 @default.
• W2038461954 hasConceptScore W2038461954C105702510 @default.
• W2038461954 hasConceptScore W2038461954C143065580 @default.
• W2038461954 hasConceptScore W2038461954C150194340 @default.
• W2038461954 hasConceptScore W2038461954C189165786 @default.
• W2038461954 hasConceptScore W2038461954C190283241 @default.
• W2038461954 hasConceptScore W2038461954C203014093 @default.
• W2038461954 hasConceptScore W2038461954C2776336362 @default.
• W2038461954 hasConceptScore W2038461954C2778486617 @default.
• W2038461954 hasConceptScore W2038461954C2780550940 @default.
• W2038461954 hasConceptScore W2038461954C2781403057 @default.
• W2038461954 hasConceptScore W2038461954C31573885 @default.
• W2038461954 hasConceptScore W2038461954C54355233 @default.
• W2038461954 hasConceptScore W2038461954C86803240 @default.
• W2038461954 hasConceptScore W2038461954C95444343 @default.
• W2038461954 hasIssue "1" @default.
• W2038461954 hasLocation W20384619541 @default.
• W2038461954 hasLocation W20384619542 @default.

• next