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• W2038463744 abstract "Type 2 diabetes is a metabolic disorder characterized by insulin resistance as well as a progressive deterioration of pancreatic β-cell mass and function. Glucagon-like peptide 1 (GLP-1), an incretin hormone secreted by intestinal L cells, is a promising therapeutic agent in the treatment of diabetes. GLP-1 analogs and enhancers constitute a novel class of anti-diabetes medications which address both the insulin secretion defect as well as the decline in β-cell mass. GLP-1 improves glucose-stimulated insulin secretion, restores glucose competence in glucose-resistant β-cells, and stimulates insulin gene expression and biosynthesis. Furthermore, GLP-1 acts as a growth factor by promoting β-cell proliferation, survival and neogenesis. This review focuses on the molecular mechanisms by which GLP-1 signaling induces β-cell mass expansion. Le diabète de type 2 est un désordre métabolique caractérisé par une résistance à l’insuline ainsi qu’une détérioration progressive de la fonction et de la masse des cellules pancréatiques β. Le glucagon-like peptide 1 (GLP-1), une hormone incrétine sécrétée par les cellules L de l’intestin, est un agent thérapeutique prometteur dans le traitement du diabète. Les analogues du GLP-1 et les composés qui prolongent son action composent une nouvelle classe de médicaments anti-diabétiques qui corrigent à la fois le défaut de sécrétion d’insuline et la réduction de la masse de cellules β. Le GLP-1 améliore la sécrétion d’insuline stimulée par le glucose, rétablit la compétence au glucose des cellules β résistantes au glucose, et stimule l’expression et la biosynthèse d’insuline. De plus, le GLP-1 agit comme un facteur de croissance en stimulant la prolifération, la survie et la néogénèse des cellules β. Cette revue de littérature est centrée sur les aux mécanismes moléculaires par lesquels le GLP-1 promeut l’expansion de la masse de cellules β." @default.
• W2038463744 created "2016-06-24" @default.
• W2038463744 creator A5035517829 @default.
• W2038463744 date "2008-02-01" @default.
• W2038463744 modified "2023-09-26" @default.
• W2038463744 title "GLP-1 receptor signaling: effects on pancreatic β-cell proliferation and survival" @default.
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• W2038463744 doi "https://doi.org/10.1016/s1262-3636(08)73398-6" @default.
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