Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038472001> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W2038472001 abstract "Doxorubicin (DOX) is a widely used antineoplastic agent that exerts cardiotoxic effects. This study analyzed the effects of a clinically relevant DOX concentration (30 μM) on Ca2+ transport in rat ventricular myocytes. DOX decreased the sarcoplasmic reticulum (SR) Ca2+ content ([Ca2+]SR) (15%, p<0.001), however without significant change in Ca2+ transient amplitude and kinetics, or in the fraction of [Ca2+]SR released at a twitch. DOX abbreviated [Ca2+]i decline of caffeine-evoked transients (p<0.001). Estimates of the integrated Ca2+ fluxes attributable to individual transporters during twitch [Ca2+]i decline indicated a small depression of SR Ca2+ uptake (12%, p<0.05), but great enhancement of Ca2+ efflux via the Na+/Ca2+ exchanger (NCX) (90%, p<0.05), so that the contribution of the latter to cytosolic Ca2+ removal more than doubled. To promote NCX-mediated Ca2+ influx in the absence of electrical stimulation, extracellular [Na+] was lowered from 140 to 105 mM. In these conditions, DOX exposure increased both the rate constant of [Ca2+]i rise (12.8±1.4 vs. 4.8±0.8 nM.s-1) and the rate of spontaneous Ca2+ transients (0.18±0.04 vs. 0.05±0.01 Hz, p<0.05). After SR function inhibition with thapsigargin, spontaneous Ca2+ transients were absent, but NCX-mediated increase in [Ca2+]i remained greater in the presence of DOX (190±35 vs. 74±18 nM.min-1, p<0.01), which was abolished by inhibition of reverse NCX with 10 μM KB-R7943 (−29±6 nM.min-1, p<0.01). The results indicate that DOX altered mainly diastolic Ca2+ handling, causing mild inhibition of SR Ca2+ uptake, but marked increase of Ca2+ transport via NCX. The latter effect does not seem to be due to thermodynamic factors, but probably to NCX stimulation, as both Ca2+ influx and efflux were enhanced." @default.
- W2038472001 created "2016-06-24" @default.
- W2038472001 creator A5002657860 @default.
- W2038472001 creator A5015556111 @default.
- W2038472001 creator A5078036167 @default.
- W2038472001 date "2014-01-01" @default.
- W2038472001 modified "2023-10-02" @default.
- W2038472001 title "Doxorubicin Stimulates the Na+/Ca2+ Exchanger in Ventricular Cardiomyocytes" @default.
- W2038472001 doi "https://doi.org/10.1016/j.bpj.2013.11.2964" @default.
- W2038472001 hasPublicationYear "2014" @default.
- W2038472001 type Work @default.
- W2038472001 sameAs 2038472001 @default.
- W2038472001 citedByCount "0" @default.
- W2038472001 crossrefType "journal-article" @default.
- W2038472001 hasAuthorship W2038472001A5002657860 @default.
- W2038472001 hasAuthorship W2038472001A5015556111 @default.
- W2038472001 hasAuthorship W2038472001A5078036167 @default.
- W2038472001 hasBestOaLocation W20384720011 @default.
- W2038472001 hasConcept C12554922 @default.
- W2038472001 hasConcept C126322002 @default.
- W2038472001 hasConcept C134018914 @default.
- W2038472001 hasConcept C158617107 @default.
- W2038472001 hasConcept C178790620 @default.
- W2038472001 hasConcept C181199279 @default.
- W2038472001 hasConcept C185592680 @default.
- W2038472001 hasConcept C200082930 @default.
- W2038472001 hasConcept C24998067 @default.
- W2038472001 hasConcept C2777146706 @default.
- W2038472001 hasConcept C2777735026 @default.
- W2038472001 hasConcept C2778500429 @default.
- W2038472001 hasConcept C28406088 @default.
- W2038472001 hasConcept C519063684 @default.
- W2038472001 hasConcept C55493867 @default.
- W2038472001 hasConcept C63645605 @default.
- W2038472001 hasConcept C71924100 @default.
- W2038472001 hasConcept C79879829 @default.
- W2038472001 hasConcept C86803240 @default.
- W2038472001 hasConcept C87975464 @default.
- W2038472001 hasConcept C98274493 @default.
- W2038472001 hasConcept C98539663 @default.
- W2038472001 hasConceptScore W2038472001C12554922 @default.
- W2038472001 hasConceptScore W2038472001C126322002 @default.
- W2038472001 hasConceptScore W2038472001C134018914 @default.
- W2038472001 hasConceptScore W2038472001C158617107 @default.
- W2038472001 hasConceptScore W2038472001C178790620 @default.
- W2038472001 hasConceptScore W2038472001C181199279 @default.
- W2038472001 hasConceptScore W2038472001C185592680 @default.
- W2038472001 hasConceptScore W2038472001C200082930 @default.
- W2038472001 hasConceptScore W2038472001C24998067 @default.
- W2038472001 hasConceptScore W2038472001C2777146706 @default.
- W2038472001 hasConceptScore W2038472001C2777735026 @default.
- W2038472001 hasConceptScore W2038472001C2778500429 @default.
- W2038472001 hasConceptScore W2038472001C28406088 @default.
- W2038472001 hasConceptScore W2038472001C519063684 @default.
- W2038472001 hasConceptScore W2038472001C55493867 @default.
- W2038472001 hasConceptScore W2038472001C63645605 @default.
- W2038472001 hasConceptScore W2038472001C71924100 @default.
- W2038472001 hasConceptScore W2038472001C79879829 @default.
- W2038472001 hasConceptScore W2038472001C86803240 @default.
- W2038472001 hasConceptScore W2038472001C87975464 @default.
- W2038472001 hasConceptScore W2038472001C98274493 @default.
- W2038472001 hasConceptScore W2038472001C98539663 @default.
- W2038472001 hasLocation W20384720011 @default.
- W2038472001 hasOpenAccess W2038472001 @default.
- W2038472001 hasPrimaryLocation W20384720011 @default.
- W2038472001 hasRelatedWork W1918855678 @default.
- W2038472001 hasRelatedWork W1967930773 @default.
- W2038472001 hasRelatedWork W2016010885 @default.
- W2038472001 hasRelatedWork W2022277009 @default.
- W2038472001 hasRelatedWork W2042646075 @default.
- W2038472001 hasRelatedWork W2052857844 @default.
- W2038472001 hasRelatedWork W2061529510 @default.
- W2038472001 hasRelatedWork W2067079349 @default.
- W2038472001 hasRelatedWork W2067918790 @default.
- W2038472001 hasRelatedWork W2071995297 @default.
- W2038472001 hasRelatedWork W2074543494 @default.
- W2038472001 hasRelatedWork W2074877422 @default.
- W2038472001 hasRelatedWork W2075017642 @default.
- W2038472001 hasRelatedWork W2078151770 @default.
- W2038472001 hasRelatedWork W2090327014 @default.
- W2038472001 hasRelatedWork W2097593721 @default.
- W2038472001 hasRelatedWork W2249770182 @default.
- W2038472001 hasRelatedWork W2390456247 @default.
- W2038472001 hasRelatedWork W2411189829 @default.
- W2038472001 hasRelatedWork W2415192506 @default.
- W2038472001 isParatext "false" @default.
- W2038472001 isRetracted "false" @default.
- W2038472001 magId "2038472001" @default.
- W2038472001 workType "article" @default.