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- W2038479905 endingPage "20556" @default.
- W2038479905 startingPage "20536" @default.
- W2038479905 abstract "Radiolabeled peptides have been the subject of intense research efforts for targeted diagnostic imaging and radiotherapy over the last 20 years. Peptides offer several advantages for receptor imaging and targeted radiotherapy. The low molecular weight of peptides allows for rapid clearance from the blood and non-target tissue, which results in favorable target-to-non-target ratios. Moreover, peptides usually display good tissue penetration and they are generally non-immunogenic. A major drawback is their potential low metabolic stability. The majority of currently used radiolabeled peptides for targeted molecular imaging and therapy of cancer is labeled with various radiometals like 99mTc, 68Ga, and 177Lu. However, over the last decade an increasing number of 18F-labeled peptides have been reported. Despite of obvious advantages of 18F like its ease of production in large quantities at high specific activity, the low β+ energy (0.64 MeV) and the favorable half-life (109.8 min), 18F-labeling of peptides remains a special challenge. The first part of this review will provide a brief overview on chemical strategies for peptide labeling with 18F. A second part will discuss recent technological advances for 18F-labeling of peptides with special focus on microfluidic technology, automation, and kit-like preparation of 18F-labeled peptides." @default.
- W2038479905 created "2016-06-24" @default.
- W2038479905 creator A5081387229 @default.
- W2038479905 creator A5089586541 @default.
- W2038479905 date "2014-12-08" @default.
- W2038479905 modified "2023-09-26" @default.
- W2038479905 title "18F-Labeled Peptides: The Future Is Bright" @default.
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- W2038479905 doi "https://doi.org/10.3390/molecules191220536" @default.
- W2038479905 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6271677" @default.
- W2038479905 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25493636" @default.
- W2038479905 hasPublicationYear "2014" @default.