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• W2038492021 abstract "Lung cancer is the leading cause of cancer-related mortality in the world, and kills more than 1 million people annually. 1 Youlden DR Cramb SM Baade PD The international epidemiology of lung cancer: geographical distribution and secular trends. J Thorac Oncol. 2008; 3: 819-831 Crossref PubMed Scopus (594) Google Scholar Non-small-cell lung cancer (NSCLC) has a 5-year survival rate of 10–15%, chiefly because only 25% of patients have disease that is amenable to curative resection. However, even in patients with early-stage disease, survival rates are much worse than they are for other common cancers. Postoperative adjuvant chemotherapy has been extensively studied in an effort to improve survival. On the basis of studies that show 4–15% improvements in 5-year survival rates, 2 International Adjuvant Lung Cancer Trial Collaborative GroupCisplatin-based adjuvant chemotherapy in patients with completely resected non-small cell lung cancer. N Engl J Med. 2004; 350: 351-360 Crossref PubMed Scopus (2058) Google Scholar , 3 Winton T Livingston R Johnson J et al. for the National Cancer Institute of Canada Clinical Trials Group and the National Cancer Institute of the United States Intergroup JBR.10 Trial InvestigatorsVinorelbine plus cisplatin vs. observation in resected non-small cell lung cancer. N Engl J Med. 2005; 352: 2589-2597 Crossref PubMed Scopus (1618) Google Scholar , 4 Douillard J-Y Rosell R DeLena M et al. Adjuvant vinorelbine plus cisplatin versus observation in patients with completely resected stage IB-IIIA non-small cell lung cancer (Adjuvant Navelbine International Trialist Association [ANITA]): a randomised controlled trial. Lancet Oncol. 2006; 7: 719-727 Summary Full Text Full Text PDF PubMed Scopus (1304) Google Scholar adjuvant chemotherapy has become the standard of care for patients with resected, stage II, or stage III disease. 5 Ettinger DS Akerley W Bepler G et al. Non-small cell lung cancer: clinical practice guidelines in oncology. J Natl Compr Canc Netw. 2008; 6: 228-269 PubMed Google Scholar , 6 Pisters KMW Evans WK Azzoli CG et al. Cancer Care Ontario and American Society of Clinical Oncology adjuvant chemotherapy and adjuvant radiation therapy for stages I–IIIA resectable non-small cell lung cancer guidelines. J Clin Oncol. 2007; 25: 5506-5518 Crossref PubMed Scopus (306) Google Scholar Adjuvant chemotherapy, with or without postoperative radiotherapy, in operable non-small-cell lung cancer: two meta-analyses of individual patient dataThe addition of adjuvant chemotherapy after surgery for patients with operable non-small-cell lung cancer improves survival, irrespective of whether chemotherapy was adjuvant to surgery alone or adjuvant to surgery plus radiotherapy. Full-Text PDF Open Access" @default.
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• W2038492021 date "2010-04-01" @default.
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• W2038492021 title "Adjuvant therapy for non-small-cell lung cancer" @default.
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• W2038492021 doi "https://doi.org/10.1016/s0140-6736(10)60454-0" @default.
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