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- W2038511713 abstract "Fifty-nine patients who sustained hyphema following blunt trauma were randomly assigned prospectively to either of two dose regimens of epsilon aminocaproic acid (Amicar®). Twenty-six took an oral dosage of 50 mg/kg (“half dose”) every four hours for five days, up to a maximum of 30 g/day, and 33 patients received 100 mg/kg (“full-dose”) every four hours up to a maximum of 30 g/day. Five patients in the full-dose group experienced dizziness, hypotension, and syncope. Half-dose Amicar® substantially reduced such serious side effects (P = 0.063), had no adverse effect on the reduced rate of recurrent hemorrhages (P = 0.22), and was more cost effective than the full-dose regimen. When the two patients in the half-dose group receiving 30 g/day of Amicar® were deleted, however, the comparison of dizziness and hypotension in the two groups became more significant (P = 0.050). The incidence of nausea and vomiting was approximately the same in both groups (P = 0.52). Serum Amicar® levels were within the range of plasminogen inhibition at both dose levels. Prior aspirin ingestion appeared to have no influence on the rate of rebleeding (P =0.58)." @default.
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- W2038511713 date "1986-01-01" @default.
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- W2038511713 title "A Comparison of Two Dose Regimens of Epsilon Aminocaproic Acid in the Prevention and Management of Secondary Traumatic Hyphemas" @default.
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- W2038511713 doi "https://doi.org/10.1016/s0161-6420(86)33784-9" @default.
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