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- W2038528029 abstract "To study whether the circulating anticoagulant, activated protein C (APC), could be a regulator of thrombin activity in basal physiological conditions, fibrinopeptide A and activated protein C levels were determined in samples from 40 healthy individuals. There was a significant inverse correlation between the fibrinopeptide A and APC levels (Spearman rank correlation R = -0.487; P = 0.0023). Because of well-known mechanisms by which decreasing APC levels could cause increased thrombin formation, we suggest that APC may downregulate thrombin activity in subjects with normal protein C levels. Regulation of thrombin formation in health is likely significant for maintaining vascular patency but its molecular mechanisms are poorly understood. The current data suggest that a single physiological anticoagulant, namely APC, may be a significant regulator of procoagulant thrombin activity." @default.
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- W2038528029 date "1997-09-01" @default.
- W2038528029 modified "2023-10-14" @default.
- W2038528029 title "Activated protein C correlates inversely with thrombin levels in resting healthy individuals" @default.
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- W2038528029 doi "https://doi.org/10.1002/(sici)1096-8652(199709)56:1<29::aid-ajh6>3.0.co;2-4" @default.
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