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• W2038534760 abstract "We sought to determine if 17-alpha-hydroxyprogesterone (17P) extends gestation vs placebo in women with preterm premature rupture of the membranes (PPROM).Women with vertex presentations with PPROM, 20-30 weeks' gestation, were randomized to receive weekly 17P or placebo in an attempt to prolong the pregnancy. A total of 69 patients (17P, n = 33; placebo, n = 36) were randomized into this study.Initial cervical dilatation, gestational age at enrollment, and interval to delivery were not different between the 2 groups (P = .914, .424, and .146, respectively). Time of randomization to delivery (P = .250), mode of delivery (relative risk, 1.16; 95% confidence interval, 0.66-2.06), and the neonatal outcome statistics of morbidity (P = .820) and mortality (relative risk, 1.28; 95% confidence interval, 0.59-2.75) were similar between the 2 groups.In patients with PPROM, 17P did not extend gestation vs placebo and cannot be recommended for treatment in such women." @default.
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• W2038534760 date "2011-01-01" @default.
• W2038534760 modified "2023-09-26" @default.
• W2038534760 title "Women with preterm premature rupture of the membranes do not benefit from weekly progesterone" @default.
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• W2038534760 doi "https://doi.org/10.1016/j.ajog.2010.08.022" @default.
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