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- W2038539751 abstract "Abstract Despite recent developments for new targeted therapies in melanoma, as BRAF inhibitors and immune‐stimulating antibodies, tumor relapse frequently follows within less than a year. Therapy resistance is explained by defects in proapoptotic signalling. Thus, efficient induction of apoptosis in tumor cells appears as predominant therapeutic goal. In apoptosis control of melanoma, the balance between pro‐ and antiapoptotic B cl‐2 proteins plays a decisive role. In particular, members of the subfamily of BH 3‐only proteins function as proapoptotic triggers, and mimetics of these proteins are already in clinical trials in other cancers. Recent experimental work has revealed that the effects of different treatments in melanoma are related to the activation of BH 3‐only proteins, and also the proapoptotic effects of BRAF inhibitors are prevented by knockdown of the BH 3‐only protein B im. Thus, melanoma therapy might be critically improved by the combination of survival pathway antagonists as BRAF inhibitors with BH 3 mimetics." @default.
- W2038539751 created "2016-06-24" @default.
- W2038539751 creator A5029406176 @default.
- W2038539751 creator A5074907520 @default.
- W2038539751 date "2014-05-28" @default.
- W2038539751 modified "2023-10-02" @default.
- W2038539751 title "BH3-only proteins - possible proapoptotic triggers for melanoma therapy" @default.
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- W2038539751 doi "https://doi.org/10.1111/exd.12399" @default.
- W2038539751 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24673301" @default.
- W2038539751 hasPublicationYear "2014" @default.
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