FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038543329> ?p ?o ?g. }

• W2038543329 endingPage "306" @default.
• W2038543329 startingPage "283" @default.
• W2038543329 abstract "1. The effects of quinacrine on the relaxation of the agonist-induced currents in response to a voltage step were investigated at voltage clamped frog end-plates. A fast perfusion technique allowed the application of known concentrations of the agonist acetylcholine (ACh) or carbachol to end-plate viewed with Nomarski optics. 2. In the presence of quinacrine, and in response to a hyperpolarizing voltage jump, an agonist-induced current shows a fast initial relaxational increase and then relaxes slowly back to a new equilibrium level. 3. The slow relaxation can be described by a single exponential with a time constant tau s . tau s gets smaller at increasing quinacrine concentrations (0--2 microM) and the decay rate constant, 1/tau s, increases linearly with quinacrine concentration. Increasing agonist concentration reduces tau s, in a manner dependent on the nature of the agonist. Tau s is markedly lengthened at more hyperpolarized potential, but this voltage effect gets less at higher concentrations of agonist. 4. These data suggest a slow voltage dependent blockage of open end-plate channels by quinacrine. The binding rate constant of quinacrine is estimated as 10(8) M-1 s-1, and the voltage dependent, backward rate constant, as 5 s-1 at -60 mV and 1 s-1 at -140 mV. These values are in fair agreement with those obtained from the analysis presented in the preceding paper. 5. The agonist concentration dependence of the blocking kinetics is compatible with a simple model for channel opening. In this model, independent sequential binding of two agonist molecules leads to an isomerization of the receptor. The intrinsic binding constant of ACh is estimated to be around 20 microM, and for carbachol around 200 microM. Distinct isomerization constants could lead to a maximal activation of 70% of the available channels by ACh, and only 40% by carbachol. 6. An example of a possible interaction in between quinacrine block and desensitization is shown. At the break of an hyperpolarizing jump which has increased quinacrine blockade, a transient increase in the synaptic current is observed with apparently a temporary reduction of the desensitization." @default.
• W2038543329 created "2016-06-24" @default.
• W2038543329 creator A5003416284 @default.
• W2038543329 creator A5003551392 @default.
• W2038543329 date "1980-09-01" @default.
• W2038543329 modified "2023-09-26" @default.
• W2038543329 title "End-plate channel opening and the kinetics of quinacrine (mepacrine) block." @default.
• W2038543329 cites W1492781998 @default.
• W2038543329 cites W1534044613 @default.
• W2038543329 cites W1538420402 @default.
• W2038543329 cites W1585319623 @default.
• W2038543329 cites W1950897149 @default.
• W2038543329 cites W1964800013 @default.
• W2038543329 cites W1965554709 @default.
• W2038543329 cites W1977106724 @default.
• W2038543329 cites W1978528850 @default.
• W2038543329 cites W1989573207 @default.
• W2038543329 cites W2007444793 @default.
• W2038543329 cites W2025137231 @default.
• W2038543329 cites W2026724487 @default.
• W2038543329 cites W2028718931 @default.
• W2038543329 cites W2036671896 @default.
• W2038543329 cites W2037432749 @default.
• W2038543329 cites W2041659810 @default.
• W2038543329 cites W2052664684 @default.
• W2038543329 cites W2053413143 @default.
• W2038543329 cites W2054693313 @default.
• W2038543329 cites W2063463822 @default.
• W2038543329 cites W2066420439 @default.
• W2038543329 cites W2070189272 @default.
• W2038543329 cites W2070722619 @default.
• W2038543329 cites W2071735918 @default.
• W2038543329 cites W2077535717 @default.
• W2038543329 cites W2087095331 @default.
• W2038543329 cites W2087379933 @default.
• W2038543329 cites W2114510024 @default.
• W2038543329 cites W2140817639 @default.
• W2038543329 cites W2163002898 @default.
• W2038543329 cites W2169669837 @default.
• W2038543329 cites W2266135483 @default.
• W2038543329 cites W2318319491 @default.
• W2038543329 cites W2336034717 @default.
• W2038543329 cites W2408831770 @default.
• W2038543329 cites W2411404977 @default.
• W2038543329 cites W4211109628 @default.
• W2038543329 cites W2469907266 @default.
• W2038543329 doi "https://doi.org/10.1113/jphysiol.1980.sp013397" @default.
• W2038543329 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1283006" @default.
• W2038543329 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6257897" @default.
• W2038543329 hasPublicationYear "1980" @default.
• W2038543329 type Work @default.
• W2038543329 sameAs 2038543329 @default.
• W2038543329 citedByCount "45" @default.
• W2038543329 crossrefType "journal-article" @default.
• W2038543329 hasAuthorship W2038543329A5003416284 @default.
• W2038543329 hasAuthorship W2038543329A5003551392 @default.
• W2038543329 hasBestOaLocation W20385433291 @default.
• W2038543329 hasConcept C113196181 @default.
• W2038543329 hasConcept C119599485 @default.
• W2038543329 hasConcept C121332964 @default.
• W2038543329 hasConcept C12554922 @default.
• W2038543329 hasConcept C126322002 @default.
• W2038543329 hasConcept C127413603 @default.
• W2038543329 hasConcept C134018914 @default.
• W2038543329 hasConcept C148898269 @default.
• W2038543329 hasConcept C170493617 @default.
• W2038543329 hasConcept C185592680 @default.
• W2038543329 hasConcept C2775910092 @default.
• W2038543329 hasConcept C2776029896 @default.
• W2038543329 hasConcept C2778938600 @default.
• W2038543329 hasConcept C2778988552 @default.
• W2038543329 hasConcept C43617362 @default.
• W2038543329 hasConcept C46141821 @default.
• W2038543329 hasConcept C55493867 @default.
• W2038543329 hasConcept C71924100 @default.
• W2038543329 hasConcept C74650414 @default.
• W2038543329 hasConcept C81370116 @default.
• W2038543329 hasConcept C86803240 @default.
• W2038543329 hasConcept C93391505 @default.
• W2038543329 hasConceptScore W2038543329C113196181 @default.
• W2038543329 hasConceptScore W2038543329C119599485 @default.
• W2038543329 hasConceptScore W2038543329C121332964 @default.
• W2038543329 hasConceptScore W2038543329C12554922 @default.
• W2038543329 hasConceptScore W2038543329C126322002 @default.
• W2038543329 hasConceptScore W2038543329C127413603 @default.
• W2038543329 hasConceptScore W2038543329C134018914 @default.
• W2038543329 hasConceptScore W2038543329C148898269 @default.
• W2038543329 hasConceptScore W2038543329C170493617 @default.
• W2038543329 hasConceptScore W2038543329C185592680 @default.
• W2038543329 hasConceptScore W2038543329C2775910092 @default.
• W2038543329 hasConceptScore W2038543329C2776029896 @default.
• W2038543329 hasConceptScore W2038543329C2778938600 @default.
• W2038543329 hasConceptScore W2038543329C2778988552 @default.
• W2038543329 hasConceptScore W2038543329C43617362 @default.
• W2038543329 hasConceptScore W2038543329C46141821 @default.
• W2038543329 hasConceptScore W2038543329C55493867 @default.
• W2038543329 hasConceptScore W2038543329C71924100 @default.
• W2038543329 hasConceptScore W2038543329C74650414 @default.

• next