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- W2038553715 abstract "The recently isolated cysteine- and arginine-rich peptides of the neutrophil primary granule and the murine intestinal Paneth cell, named defensins or corticostatins, have a number of distinct biological properties. We report the effects of three of these peptides HP-1, HP-1–56 and HP-4 on the incorporation of [3H]thymidine into the DNA of the leukemic cell line HL60. HP-1 and HP-1–56, but not HP-4, inhibited DNA synthesis at 1–50 nM without causing cell death. At higher concentrations the effect was reversed, resulting in a small, but statistically significant increase in DNA synthesis at 1 μM. In contrast HP-4 had no effect on HL60 cells at nanomolar concentrations but was strongly cytotoxic at micromolar concentrations." @default.
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- W2038553715 date "1991-08-01" @default.
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- W2038553715 title "The effect of HP-1 and related neutrophil granule peptides on DNA synthesis in HL60 cells" @default.
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- W2038553715 doi "https://doi.org/10.1016/0167-0115(91)90476-w" @default.
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