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- W2038562747 abstract "Dengue control is in trouble. Since the severe form of dengue infection was described more than 50 years ago, this disease has spread to every corner of the tropics. 1 Hammon WM Rudnick A Sather GE Rogers KD Morse LJ New hemorrhagic fevers of children in the Philippines and Thailand. Trans Assoc Am Physicians. 1960; 73: 140-155 PubMed Google Scholar , 2 Brady OJ Gething PW Bhatt S et al. Refining the global spatial limits of dengue virus transmission by evidence-based consensus. PLoS Negl Trop Dis. 2012; 6: e1760 Crossref PubMed Scopus (1088) Google Scholar , 3 Bhatt S Gething PW Brady OJ et al. The global distribution and burden of dengue. Nature. 2013; 496: 504-507 Crossref PubMed Scopus (5968) Google Scholar In 2010, 4 billion people were at risk of infection with any of the four dengue viruses (DENV1–4), more than 390 million individuals were infected, and 96 million had overt disease. 3 Bhatt S Gething PW Brady OJ et al. The global distribution and burden of dengue. Nature. 2013; 496: 504-507 Crossref PubMed Scopus (5968) Google Scholar During a dengue infection, a small subset of individuals with circulating infection-enhancing dengue antibodies are at risk of an abrupt onset of acute vascular permeability accompanied by abnormalities in haemostasis, potentially leading to shock, severe bleeding, and death. 4 Halstead SB Dengue. Lancet. 2007; 370: 1644-1652 Summary Full Text Full Text PDF PubMed Scopus (1189) Google Scholar This severe outcome typically occurs at the time of defervescence after several days of the symptoms of classic dengue fever. Additionally, dengue infections can have unfavourable outcomes in elderly individuals who have pre-existing chronic disorders. These clinical courses create a cruel diagnostic dilemma for physicians and have led to many efforts to identify clinical signs and symptoms premonitory of severe dengue. 5 Leo YS Gan VC Ng EL et al. Utility of warning signs in guiding admission and predicting severe disease in adult dengue. BMC Infect Dis. 2013; 13: 498 Crossref PubMed Scopus (53) Google Scholar Meanwhile, despite the availability of many powerful insecticides, mosquito abatement efforts directed at the control or eradication of the dengue vector Aedes aegypti have conspicuously and universally failed. 6 Gubler DJ Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol. 2002; 10: 100-103 Summary Full Text Full Text PDF PubMed Scopus (1169) Google Scholar Efficacy and safety of celgosivir in patients with dengue fever (CELADEN): a phase 1b, randomised, double-blind, placebo-controlled, proof-of-concept trialAlthough generally safe and well tolerated, celgosivir does not seem to reduce viral load or fever burden in patients with dengue. Full-Text PDF" @default.
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- W2038562747 date "2014-08-01" @default.
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- W2038562747 title "Stumbles on the path to dengue control" @default.
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