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• W2038563404 abstract "Background . Novel therapies need to be evaluated in a relevant large animal model that mimics the clinical course and treatment in a reasonable time frame. To reliably assess therapeutic efficacy, knowledge regarding the translational model and the course of disease is needed. Methods . Landrace pigs were subjected to a transient occlusion of the proximal left circumflex artery (LCx)<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mo stretchy=false>(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>6</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>or mid-left anterior descending artery (LAD)<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mo stretchy=false>(</mml:mo><mml:mi>n</mml:mi><mml:mo>=</mml:mo><mml:mn>6</mml:mn><mml:mo stretchy=false>)</mml:mo></mml:math>for 150 min. Cardiac function was evaluated before by 2D echocardiography or 3D echocardiography and pressure-volume loop analysis. At 12 weeks of follow-up the heart was excised for histological analysis and infarct size calculations. Results . Directly following AMI, LVEF was severely reduced compared to baseline in the LAD group<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M3><mml:mrow><mml:mfenced separators=|><mml:mrow><mml:mo>-</mml:mo><mml:mn>17.1</mml:mn><mml:mo>±</mml:mo><mml:mn>1.6</mml:mn><mml:mi>%</mml:mi><mml:mo>,</mml:mo><mml:mi> </mml:mi><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.009</mml:mn></mml:mrow></mml:mfenced></mml:mrow></mml:math>compared to only a moderate reduction in the LCx group<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M4><mml:mrow><mml:mfenced separators=|><mml:mrow><mml:mo>-</mml:mo><mml:mn>5.9</mml:mn><mml:mo>±</mml:mo><mml:mn>1.5</mml:mn><mml:mi>%</mml:mi><mml:mo>,</mml:mo><mml:mi> </mml:mi><mml:mi>P</mml:mi><mml:mo>=</mml:mo><mml:mn>0.02</mml:mn></mml:mrow></mml:mfenced></mml:mrow></mml:math>and this effect remained unchanged during 12 weeks of follow-up. Conclusion . Two models of chronic MI, representative for different patient groups, can reproducibly be created through clinically relevant ischemia-reperfusion of the mid-LAD and proximal LCx." @default.
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• W2038563404 date "2015-01-01" @default.
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• W2038563404 title "Cardiac Function in a Long-Term Follow-Up Study of Moderate and Severe Porcine Model of Chronic Myocardial Infarction" @default.
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