FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038583828> ?p ?o ?g. }

• W2038583828 endingPage "695" @default.
• W2038583828 startingPage "685" @default.
• W2038583828 abstract "3,5,3′-Triiodo-L-thyronine-125I (T3-125I) metabolism was studied in nine euthyroid human subjects on blocking doses of nonradioactive iodide. After the intravenous injection of T3-125I, the fractional disappearance rate of plasma radioactivity progressively disappearance rate of plasma radioactivity progressively decreased with time. Analysis of individual plasma samples by dialysis, electrophoretic, and extraction techniques revealed three radioactive components: T3-125I, iodide-125I, and an unidentified material which was nonextractable in acid butanol (NE125I). Ne125I rose to maximal levels 24-36 hr after injection of T3-125I and then decreased with a fractional rate which approached, after 12-14 days, approximately 0.05 day-1 (t½ = 14 days). The plasma T3-125I concentration, obtained by subtraction of iodide-125I and NE125I from the plasma total 125I, declined at a constant fractional rate with time with a t½ of 1.5 days. Qualitatively similar results were obtained in rats. After 72 hr, 57% of the plasma and 40% of the liver radioactivity was NE125I. Chromatographic purification of the T3-125I before injection did not alter these results. The extrathyroidal origin of NE125I was further demonstrated by similar results in thyroidectomized rats maintained on thyroxine. NE125I from human sera separated from the other radioiodinated substances by ion-exchange chromatography was quantitatively precipitated by trichloracetic acid, not dialyzable, insoluble in CHCl3:CH2OH, and migrated with albumin during starch-gel electrophoresis. Based on these properties, NE125I was tentatively identified as iodoalbumin. Observations in rats equilibrated with 125I, as well as nonradioactive iodine determinations in human sera before and after acid butanol extraction, indicate that 10-20% of the serum organic iodine is in the form of iodoprotein. Our studies suggest that this moiety may be derived at least in part from the peripheral metabolism of the thyroid hormones." @default.
• W2038583828 created "2016-06-24" @default.
• W2038583828 creator A5058865612 @default.
• W2038583828 creator A5059616408 @default.
• W2038583828 date "1969-04-01" @default.
• W2038583828 modified "2023-10-18" @default.
• W2038583828 title "Formation of iodoprotein during the peripheral metabolism of 35,3′-triiodo-l-thyronine-125I in the euthyroid man and rat" @default.
• W2038583828 cites W187320011 @default.
• W2038583828 cites W1893651774 @default.
• W2038583828 cites W1963864212 @default.
• W2038583828 cites W1972041908 @default.
• W2038583828 cites W1976991776 @default.
• W2038583828 cites W1985096751 @default.
• W2038583828 cites W1994463804 @default.
• W2038583828 cites W2004298538 @default.
• W2038583828 cites W2013426106 @default.
• W2038583828 cites W2028472250 @default.
• W2038583828 cites W2031426804 @default.
• W2038583828 cites W2034474248 @default.
• W2038583828 cites W2038884582 @default.
• W2038583828 cites W2042157916 @default.
• W2038583828 cites W2047028143 @default.
• W2038583828 cites W2047792055 @default.
• W2038583828 cites W2051760702 @default.
• W2038583828 cites W2064881443 @default.
• W2038583828 cites W2065510063 @default.
• W2038583828 cites W2075178327 @default.
• W2038583828 cites W2076965478 @default.
• W2038583828 cites W2081705023 @default.
• W2038583828 cites W2083486660 @default.
• W2038583828 cites W2085772349 @default.
• W2038583828 cites W2094181137 @default.
• W2038583828 cites W2117517897 @default.
• W2038583828 cites W2164342395 @default.
• W2038583828 cites W2236091398 @default.
• W2038583828 cites W2319771387 @default.
• W2038583828 cites W2415730569 @default.
• W2038583828 cites W94830663 @default.
• W2038583828 doi "https://doi.org/10.1172/jci106026" @default.
• W2038583828 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/322273" @default.
• W2038583828 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/5774106" @default.
• W2038583828 hasPublicationYear "1969" @default.
• W2038583828 type Work @default.
• W2038583828 sameAs 2038583828 @default.
• W2038583828 citedByCount "45" @default.
• W2038583828 countsByYear W20385838282017 @default.
• W2038583828 crossrefType "journal-article" @default.
• W2038583828 hasAuthorship W2038583828A5058865612 @default.
• W2038583828 hasAuthorship W2038583828A5059616408 @default.
• W2038583828 hasBestOaLocation W20385838281 @default.
• W2038583828 hasConcept C126322002 @default.
• W2038583828 hasConcept C134018914 @default.
• W2038583828 hasConcept C146543888 @default.
• W2038583828 hasConcept C176685330 @default.
• W2038583828 hasConcept C178790620 @default.
• W2038583828 hasConcept C185592680 @default.
• W2038583828 hasConcept C2776125364 @default.
• W2038583828 hasConcept C2777195454 @default.
• W2038583828 hasConcept C2778870691 @default.
• W2038583828 hasConcept C43617362 @default.
• W2038583828 hasConcept C539932907 @default.
• W2038583828 hasConcept C55493867 @default.
• W2038583828 hasConcept C62231903 @default.
• W2038583828 hasConcept C71315377 @default.
• W2038583828 hasConcept C71924100 @default.
• W2038583828 hasConceptScore W2038583828C126322002 @default.
• W2038583828 hasConceptScore W2038583828C134018914 @default.
• W2038583828 hasConceptScore W2038583828C146543888 @default.
• W2038583828 hasConceptScore W2038583828C176685330 @default.
• W2038583828 hasConceptScore W2038583828C178790620 @default.
• W2038583828 hasConceptScore W2038583828C185592680 @default.
• W2038583828 hasConceptScore W2038583828C2776125364 @default.
• W2038583828 hasConceptScore W2038583828C2777195454 @default.
• W2038583828 hasConceptScore W2038583828C2778870691 @default.
• W2038583828 hasConceptScore W2038583828C43617362 @default.
• W2038583828 hasConceptScore W2038583828C539932907 @default.
• W2038583828 hasConceptScore W2038583828C55493867 @default.
• W2038583828 hasConceptScore W2038583828C62231903 @default.
• W2038583828 hasConceptScore W2038583828C71315377 @default.
• W2038583828 hasConceptScore W2038583828C71924100 @default.
• W2038583828 hasIssue "4" @default.
• W2038583828 hasLocation W20385838281 @default.
• W2038583828 hasLocation W20385838282 @default.
• W2038583828 hasLocation W20385838283 @default.
• W2038583828 hasLocation W20385838284 @default.
• W2038583828 hasOpenAccess W2038583828 @default.
• W2038583828 hasPrimaryLocation W20385838281 @default.
• W2038583828 hasRelatedWork W1980166143 @default.
• W2038583828 hasRelatedWork W2026117978 @default.
• W2038583828 hasRelatedWork W2063979288 @default.
• W2038583828 hasRelatedWork W2067752680 @default.
• W2038583828 hasRelatedWork W2083970607 @default.
• W2038583828 hasRelatedWork W2097476982 @default.
• W2038583828 hasRelatedWork W2106687377 @default.
• W2038583828 hasRelatedWork W2155469790 @default.
• W2038583828 hasRelatedWork W2181723302 @default.
• W2038583828 hasRelatedWork W2095364283 @default.
• W2038583828 hasVolume "48" @default.

• next