FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038595962> ?p ?o ?g. }

• W2038595962 endingPage "222" @default.
• W2038595962 startingPage "217" @default.
• W2038595962 abstract "We have examined the functional consequences of ADP-ribosyltransferase modification of Ras by the exoenzyme S (ExoS) protein of Pseudomonas aeruginosa. ExoS has been shown previously to ADP-ribosylate a number of proteins, including members of the Ras superfamily, which play an essential role in the processes of cell proliferation, differentiation, motility and cell division. HeLa and NIH3T3 cells were infected with ExoS protein, which was delivered via the type III secretion system of the heterologous host Yersinia pseudotuberculosis. Infection of mammalian cells with ExoS results in a change in the ratio of GTP/GDP bound directly to Ras in vivo. This ADP-ribosylation of Ras in vivo is mediated by the C-terminal domain of ExoS. Further, ExoS ADP-ribosylation of Ras in vivo inhibits activation of Ras and the ability to interact with the Ras binding domain of Raf upon stimulation with epidermal growth factor (EGF). In the present study, we show that ExoS activity does not interfere with EGF receptor phosphorylation itself, nor with the formation of a Grb2-activated Shc complex upon EGF stimulation, consistent with ExoS blockage of this mitogenic signalling pathway at the level of Ras. This is further supported by our observation of a substantial inhibition of extracellular signal-regulated kinase and protein kinase B/Akt kinase activation in response to EGF upon ExoS infection. In conclusion, in the present study, the consequences of ExoS infection on Ras effector pathway in vivo have been defined." @default.
• W2038595962 created "2016-06-24" @default.
• W2038595962 creator A5040363208 @default.
• W2038595962 creator A5044229149 @default.
• W2038595962 creator A5048866051 @default.
• W2038595962 creator A5049441983 @default.
• W2038595962 creator A5064958032 @default.
• W2038595962 date "2000-03-27" @default.
• W2038595962 modified "2023-10-17" @default.
• W2038595962 title "Ras effector pathway activation by epidermal growth factor is inhibited in vivo by exoenzyme S ADP-ribosylation of Ras" @default.
• W2038595962 cites W1479869774 @default.
• W2038595962 cites W1521152447 @default.
• W2038595962 cites W1562699269 @default.
• W2038595962 cites W1572954385 @default.
• W2038595962 cites W158273916 @default.
• W2038595962 cites W1653017307 @default.
• W2038595962 cites W1795056021 @default.
• W2038595962 cites W1821042112 @default.
• W2038595962 cites W1876103858 @default.
• W2038595962 cites W1932304369 @default.
• W2038595962 cites W1956661481 @default.
• W2038595962 cites W1971877605 @default.
• W2038595962 cites W1977598234 @default.
• W2038595962 cites W1977701732 @default.
• W2038595962 cites W1979027806 @default.
• W2038595962 cites W1980981080 @default.
• W2038595962 cites W1981464009 @default.
• W2038595962 cites W1987850172 @default.
• W2038595962 cites W1999805805 @default.
• W2038595962 cites W2009235369 @default.
• W2038595962 cites W2015161749 @default.
• W2038595962 cites W2016955301 @default.
• W2038595962 cites W2018531075 @default.
• W2038595962 cites W2023100624 @default.
• W2038595962 cites W2031610264 @default.
• W2038595962 cites W2045500858 @default.
• W2038595962 cites W2046867705 @default.
• W2038595962 cites W2047599628 @default.
• W2038595962 cites W2075709767 @default.
• W2038595962 cites W2081966923 @default.
• W2038595962 cites W2091066588 @default.
• W2038595962 cites W2094171533 @default.
• W2038595962 cites W2094761758 @default.
• W2038595962 cites W2095416319 @default.
• W2038595962 cites W2096791952 @default.
• W2038595962 cites W2117772438 @default.
• W2038595962 cites W2120339843 @default.
• W2038595962 cites W2122965577 @default.
• W2038595962 cites W2144361833 @default.
• W2038595962 cites W2146675221 @default.
• W2038595962 cites W2150418339 @default.
• W2038595962 cites W2152267183 @default.
• W2038595962 cites W2152450950 @default.
• W2038595962 cites W2175146729 @default.
• W2038595962 cites W2430072599 @default.
• W2038595962 cites W2468949329 @default.
• W2038595962 cites W4243003607 @default.
• W2038595962 doi "https://doi.org/10.1042/bj3470217" @default.
• W2038595962 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1220951" @default.
• W2038595962 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10727422" @default.
• W2038595962 hasPublicationYear "2000" @default.
• W2038595962 type Work @default.
• W2038595962 sameAs 2038595962 @default.
• W2038595962 citedByCount "34" @default.
• W2038595962 countsByYear W20385959622014 @default.
• W2038595962 countsByYear W20385959622017 @default.
• W2038595962 countsByYear W20385959622018 @default.
• W2038595962 crossrefType "journal-article" @default.
• W2038595962 hasAuthorship W2038595962A5040363208 @default.
• W2038595962 hasAuthorship W2038595962A5044229149 @default.
• W2038595962 hasAuthorship W2038595962A5048866051 @default.
• W2038595962 hasAuthorship W2038595962A5049441983 @default.
• W2038595962 hasAuthorship W2038595962A5064958032 @default.
• W2038595962 hasBestOaLocation W20385959622 @default.
• W2038595962 hasConcept C127812441 @default.
• W2038595962 hasConcept C170493617 @default.
• W2038595962 hasConcept C184235292 @default.
• W2038595962 hasConcept C2776362946 @default.
• W2038595962 hasConcept C51785407 @default.
• W2038595962 hasConcept C55493867 @default.
• W2038595962 hasConcept C57074206 @default.
• W2038595962 hasConcept C62478195 @default.
• W2038595962 hasConcept C75217442 @default.
• W2038595962 hasConcept C86803240 @default.
• W2038595962 hasConcept C95444343 @default.
• W2038595962 hasConcept C97029542 @default.
• W2038595962 hasConceptScore W2038595962C127812441 @default.
• W2038595962 hasConceptScore W2038595962C170493617 @default.
• W2038595962 hasConceptScore W2038595962C184235292 @default.
• W2038595962 hasConceptScore W2038595962C2776362946 @default.
• W2038595962 hasConceptScore W2038595962C51785407 @default.
• W2038595962 hasConceptScore W2038595962C55493867 @default.
• W2038595962 hasConceptScore W2038595962C57074206 @default.
• W2038595962 hasConceptScore W2038595962C62478195 @default.
• W2038595962 hasConceptScore W2038595962C75217442 @default.
• W2038595962 hasConceptScore W2038595962C86803240 @default.
• W2038595962 hasConceptScore W2038595962C95444343 @default.
• W2038595962 hasConceptScore W2038595962C97029542 @default.

• next