FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2038597029> ?p ?o ?g. }

• W2038597029 endingPage "163" @default.
• W2038597029 startingPage "156" @default.
• W2038597029 abstract "Hematogenous metastasis is one of the most important factors determining the outcome of the patients with salivary adenoid cystic carcinoma (SACC). In the present study, we examined expression profile of genes in SACC cell lines to look for molecules responsible for its unique metastatic trait. A transcriptomic microarray analysis between the lower lung-metastatic rate cell line SACC-83 and the higher lung-metastatic rate cell line SACC-LM were performed, and eight genes, showed by microarray to be highly expressed in SACC-LM, were picked for validation by quantitative real-time PCR. Among the genes, the expression of epiregulin, a novel member of epidermal growth factor family, was 350-folds higher in SACC-LM than in SACC-83. Accordingly, we examined the effects of epiregulin on migration and invasion in SACC-83 as well as its targeted downstream molecules, and found that epiregulin could promote in vitro migration and invasion in SACC-83. Furthermore, epiregulin not only induced activation of both ERK1/2 and Akt, but also expression of COX-2. In addition, all these effects could be partially blocked by U0126, a specific inhibitor of mitogen-activated protein kinase kinase (MEK or MAPKK), or LY294002, a specific inhibitor of phosphatidylinositol 3-kinase (PI3K). Conclusively, the results suggest that epiregulin may play an important role in lung metastasis of SACC." @default.
• W2038597029 created "2016-06-24" @default.
• W2038597029 creator A5011440708 @default.
• W2038597029 creator A5014782194 @default.
• W2038597029 creator A5023419739 @default.
• W2038597029 creator A5040577811 @default.
• W2038597029 creator A5046819496 @default.
• W2038597029 date "2009-02-01" @default.
• W2038597029 modified "2023-10-16" @default.
• W2038597029 title "Epiregulin promotes migration and invasion of salivary adenoid cystic carcinoma cell line SACC-83 through activation of ERK and Akt" @default.
• W2038597029 cites W1520425169 @default.
• W2038597029 cites W1578523240 @default.
• W2038597029 cites W1607351680 @default.
• W2038597029 cites W1613477746 @default.
• W2038597029 cites W1971989446 @default.
• W2038597029 cites W1978846041 @default.
• W2038597029 cites W1980830316 @default.
• W2038597029 cites W1990316038 @default.
• W2038597029 cites W1995242599 @default.
• W2038597029 cites W2014169920 @default.
• W2038597029 cites W2014392738 @default.
• W2038597029 cites W2015934251 @default.
• W2038597029 cites W2018896819 @default.
• W2038597029 cites W2029081250 @default.
• W2038597029 cites W2034855589 @default.
• W2038597029 cites W2040655951 @default.
• W2038597029 cites W2048296732 @default.
• W2038597029 cites W2060346337 @default.
• W2038597029 cites W2082225843 @default.
• W2038597029 cites W2084978253 @default.
• W2038597029 cites W2085043050 @default.
• W2038597029 cites W2095922927 @default.
• W2038597029 cites W2097705418 @default.
• W2038597029 cites W2097997344 @default.
• W2038597029 cites W2107277218 @default.
• W2038597029 cites W2107876629 @default.
• W2038597029 cites W2116762360 @default.
• W2038597029 cites W2117263216 @default.
• W2038597029 cites W2118375252 @default.
• W2038597029 cites W2119465831 @default.
• W2038597029 cites W2120026123 @default.
• W2038597029 cites W2128487347 @default.
• W2038597029 cites W2146531551 @default.
• W2038597029 cites W2155230904 @default.
• W2038597029 cites W2182021524 @default.
• W2038597029 cites W2340830559 @default.
• W2038597029 doi "https://doi.org/10.1016/j.oraloncology.2008.04.009" @default.
• W2038597029 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18620900" @default.
• W2038597029 hasPublicationYear "2009" @default.
• W2038597029 type Work @default.
• W2038597029 sameAs 2038597029 @default.
• W2038597029 citedByCount "48" @default.
• W2038597029 countsByYear W20385970292012 @default.
• W2038597029 countsByYear W20385970292013 @default.
• W2038597029 countsByYear W20385970292014 @default.
• W2038597029 countsByYear W20385970292015 @default.
• W2038597029 countsByYear W20385970292016 @default.
• W2038597029 countsByYear W20385970292017 @default.
• W2038597029 countsByYear W20385970292018 @default.
• W2038597029 countsByYear W20385970292019 @default.
• W2038597029 countsByYear W20385970292020 @default.
• W2038597029 countsByYear W20385970292021 @default.
• W2038597029 countsByYear W20385970292022 @default.
• W2038597029 countsByYear W20385970292023 @default.
• W2038597029 crossrefType "journal-article" @default.
• W2038597029 hasAuthorship W2038597029A5011440708 @default.
• W2038597029 hasAuthorship W2038597029A5014782194 @default.
• W2038597029 hasAuthorship W2038597029A5023419739 @default.
• W2038597029 hasAuthorship W2038597029A5040577811 @default.
• W2038597029 hasAuthorship W2038597029A5046819496 @default.
• W2038597029 hasConcept C184235292 @default.
• W2038597029 hasConcept C2776362946 @default.
• W2038597029 hasConcept C2777546739 @default.
• W2038597029 hasConcept C2777968868 @default.
• W2038597029 hasConcept C2778308172 @default.
• W2038597029 hasConcept C2779231225 @default.
• W2038597029 hasConcept C2780806702 @default.
• W2038597029 hasConcept C502942594 @default.
• W2038597029 hasConcept C54355233 @default.
• W2038597029 hasConcept C57074206 @default.
• W2038597029 hasConcept C62478195 @default.
• W2038597029 hasConcept C75217442 @default.
• W2038597029 hasConcept C81885089 @default.
• W2038597029 hasConcept C86554907 @default.
• W2038597029 hasConcept C86803240 @default.
• W2038597029 hasConcept C95444343 @default.
• W2038597029 hasConceptScore W2038597029C184235292 @default.
• W2038597029 hasConceptScore W2038597029C2776362946 @default.
• W2038597029 hasConceptScore W2038597029C2777546739 @default.
• W2038597029 hasConceptScore W2038597029C2777968868 @default.
• W2038597029 hasConceptScore W2038597029C2778308172 @default.
• W2038597029 hasConceptScore W2038597029C2779231225 @default.
• W2038597029 hasConceptScore W2038597029C2780806702 @default.
• W2038597029 hasConceptScore W2038597029C502942594 @default.
• W2038597029 hasConceptScore W2038597029C54355233 @default.
• W2038597029 hasConceptScore W2038597029C57074206 @default.
• W2038597029 hasConceptScore W2038597029C62478195 @default.
• W2038597029 hasConceptScore W2038597029C75217442 @default.

• next