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• W2038604382 endingPage "2076" @default.
• W2038604382 startingPage "2064" @default.
• W2038604382 abstract "We have examined the effects of the tachykinin substance P on the action potential of lamprey mechanosensory dorsal cells. Substance P increased the spike duration and reduced the afterhyperpolarization. These effects were mimicked by stimulation of the dorsal root, which contains tachykinin-like immunoreactive fibres. The tachykinin antagonist spantide II blocked the effects of both substance P and dorsal root stimulation. The spike broadening was voltage-dependent, and was due to the reduction of a 4-aminopyridine-sensitive potassium conductance. The spike broadening was mimicked by G-protein activators and blocked by the G-protein inhibitor GDPbetaS. Pertussis toxin did not block the effects of substance P. The spike broadening was blocked by the protein kinase C and cAMP-dependent protein kinase inhibitor H7, and by the specific protein kinase C antagonist chelerythrine, but not by the cAMP and cGMP-dependent protein kinase inhibitor H8. The phorbol ester phorbol 12,13-dibutyrate mimicked and blocked the effects of substance P, supporting the role of protein kinase C in the spike modulation. The adenylate cyclase activator forskolin and the cAMP agonist SpcAMPs mimicked but did not block the effects of substance P on the spike duration, suggesting that protein kinase A also modulates the dorsal cell action potential, but that substance P acts independently of this pathway. Substance P also increased the excitability of the dorsal cells. This effect was blocked by 4-AP, PDBu and chelerythrine, but not by H8, suggesting that the increase in excitability shares the same intracellular and effector pathways as the spike broadening." @default.
• W2038604382 created "2016-06-24" @default.
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• W2038604382 creator A5082733472 @default.
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• W2038604382 date "1997-10-01" @default.
• W2038604382 modified "2023-10-03" @default.
• W2038604382 title "Substance P Modulates Sensory Action Potentials in the Lamprey Via a Protein Kinase C-Mediated Reduction of a 4-Aminopyridine-Sensitive Potassium Conductance" @default.
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• W2038604382 doi "https://doi.org/10.1111/j.1460-9568.1997.tb01374.x" @default.
• W2038604382 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9421167" @default.
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