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• W2038606961 abstract "ErbB signaling increases protein levels of multiple EGF-like growth factors in epithelial cells. To better understand this process, we examined the effects of EGF receptor stimulation on the transcription and mRNA stability of TGF-α, amphiregulin (AR), and heparin-binding EGF-like growth factor (HB-EGF) in human keratinocytes. EGF stimulation increased transcription of TGF-α, AR, and HB-EGF by 3- to 4-fold within 1 to 2 h. However, AR and HB-EGF mRNA levels peaked at 2 h and then rapidly declined, whereas TGF-α transcripts remained elevated for at least 6 h. Actinomycin D decay experiments yielded the rank order of transcript stability TGF-α > AR > HB-EGF. Interestingly, ligand treatment appeared to stabilize TGF-α and AR mRNAs, whereas HB-EGF transcripts were destabilized. These data demonstrate that gene-specific alterations in gene transcription and mRNA stability play important roles in the temporal regulation of EGF-like growth factor gene expression." @default.
• W2038606961 created "2016-06-24" @default.
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• W2038606961 date "1999-11-01" @default.
• W2038606961 modified "2023-09-26" @default.
• W2038606961 title "Differential Regulation of EGF-like Growth Factor Genes in Human Keratinocytes" @default.
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• W2038606961 doi "https://doi.org/10.1006/bbrc.1999.1654" @default.
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